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Physiology

মোট প্রশ্ন৮৮৮এই পাতা১০০প্রতি পাতা১০০
ঘনত্ব
উত্তর
উত্তরিতবর্তমানপুনরায় দেখুনঅসম্পূর্ণ

Physiology

PrepBank · পাতা / · ৪০১৫০০ / ৮৮৮

৪০১.
MW of Albumin
  1. 69000
  2. 156000
  3. 400000
  4. 690000
সঠিক উত্তর:
69000
উত্তর
সঠিক উত্তর:
69000
৪০২.
Maturation of the erythroblast involves except:
  1. A decrease in cell size
  2. Decreased condensation and finally pyknosis of the nucleus
  3. Accumulation of Hb
  4. A change in staining reaction of the cytoplasm from basophil to eosinophil.
সঠিক উত্তর:
Decreased condensation and finally pyknosis of the nucleus
উত্তর
সঠিক উত্তর:
Decreased condensation and finally pyknosis of the nucleus
ব্যাখ্যা
Increased condensation and finally pyknosis of the nucleus
৪০৩.
Lysis of blood clots by;
  1. Fibrin
  2. Thrombin
  3. Fibrinogen
  4. Plasmin
সঠিক উত্তর:
Plasmin
উত্তর
সঠিক উত্তর:
Plasmin
৪০৪.
Non-chromosomal DNA found in-
  1. RNA
  2. Nucleus
  3. Mitochondria
  4. Centrosome
সঠিক উত্তর:
Mitochondria
উত্তর
সঠিক উত্তর:
Mitochondria
৪০৫.
Which organelle is important in specialized cellular signalling?
  1. Endoplasmic reticulum
  2. Golgi apparatus
  3. Ribosome
  4. Mitochondria
সঠিক উত্তর:
Mitochondria
উত্তর
সঠিক উত্তর:
Mitochondria
ব্যাখ্যা
Explanations:
Cells contain a variety of organelles that perform specialized cell functions. The nucleus is an organelle that contains DNA and is the site of gene transcription. The endoplasmic reticulum and the Golgi apparatus are important in protein processing and the targeting of proteins to correct compartments within the cell. Lysosomes and peroxisomes are membranebound organelles that contribute to protein and lipid processing. Mitochondria are organelles that allow for oxidative phosphorylation in eukaryotic cells and also are important in specialized cellular signaling.
৪০৬.
Factors increase prolactin secretion?
  1. Estrogen
  2. Bromocriptine
  3. Dopamine
  4. Somatostatin
সঠিক উত্তর:
Estrogen
উত্তর
সঠিক উত্তর:
Estrogen
৪০৭.
Which stimulates secretion of uterine milk?
  1. ক) LH
  2. খ) FSH
  3. গ) Estrogen
  4. ঘ) Progesterone
সঠিক উত্তর:
ঘ) Progesterone
উত্তর
সঠিক উত্তর:
ঘ) Progesterone
৪০৮.
The decrease in O2 affinity of hemoglobin when the pH of blood falls is called the
  1. ক) Haldane effect
  2. খ) Bohr Effect
  3. গ) Donnean effect
  4. ঘ) Channel effect
সঠিক উত্তর:
খ) Bohr Effect
উত্তর
সঠিক উত্তর:
খ) Bohr Effect
ব্যাখ্যা
[Ganong 24th p-643]
৪০৯.
Accessory digestive organs excludes
  1. Teeth
  2. Tongue
  3. Mouth
  4. Salivary glands
সঠিক উত্তর:
Mouth
উত্তর
সঠিক উত্তর:
Mouth
ব্যাখ্যা

Accessory digestive organs are those which help primary digestive organs in the process of digestion. Accessory digestive organs are:
• Teeth
• Tongue
• Salivary glands
• Exocrine part of pancreas
• Liver
• Gallbladder

৪১০.
Nerve cells in the anterior gray columns
  1. Multipolar
  2. Large Axons pass out in the anterior nerve roots as y-efferents
  3. Small Axons pass out in the anterior nerve roots as a-efferents
  4. None
সঠিক উত্তর:
Multipolar
উত্তর
সঠিক উত্তর:
Multipolar
ব্যাখ্যা
Nerve cells in the anterior gray columns
• Large & multipolar and  Axons pass out in the anterior nerve roots as a-efferents
• Smaller nerve cells are multipolar and Axons pass out in anterior roots as y- efferents
৪১১.
Bifid broad P wave indicates hypertrophy of
  1. Left atrium
  2. Right atrium
  3. Left ventricle
  4. Right ventricle
সঠিক উত্তর:
Left atrium
উত্তর
সঠিক উত্তর:
Left atrium
ব্যাখ্যা

Explanation:
'P' wave may become tall peaked or broad and bifid (notched)
Tall, peaked: right atrial hypertrophy
Bifid broad: left atrial hypertrophy

৪১২.
Manifestations of shock includes all of the following except?
  1. Decrease in cardiac output
  2. Low blood pressure
  3. Rapid thready pulse
  4. Decrease in respiratory rate
সঠিক উত্তর:
Decrease in respiratory rate
উত্তর
সঠিক উত্তর:
Decrease in respiratory rate
ব্যাখ্যা

Explanation:
Manifestations of shock
• Decrease in cardiac output
• Low blood pressure
• Rapid thready pulse
• Pale and cold skin
• Increase in respiratory rate
• Restless or lethargy

৪১৩.
Urine volume can be as low as ... L/day in a dehydrated person?
  1. 0.5
  2. 1.0
  3. 1.5
  4. 2.0
সঠিক উত্তর:
0.5
উত্তর
সঠিক উত্তর:
0.5
ব্যাখ্যা
306

Urine volume can be as low as 0.5 L/day in a dehydrated person or as high as 20 L/day in a person who has been drinking tremendous amounts of water.

৪১৪.
At a normal heart rate, the duration(second) of ventricular systole is
  1. ক) 0.1
  2. খ) 0.3
  3. গ) 0.5
  4. ঘ) 0.7
সঠিক উত্তর:
খ) 0.3
উত্তর
সঠিক উত্তর:
খ) 0.3
ব্যাখ্যা

Explanation:
At a normal heart rate the duration of systole and diastole are:
Atrial systole: 0.1 second
Atrial diastole: 0.7 second
Ventricular systole: 0.3 second
Ventricular diastole: 0.5 second

৪১৫.
RBCs
  1. ক) Colourless
  2. খ) Disk shaped
  3. গ) Nucleus present
  4. ঘ) Granules present
সঠিক উত্তর:
খ) Disk shaped
উত্তর
সঠিক উত্তর:
খ) Disk shaped
৪১৬.
Receptor for pain
  1. ক) Pacinian corpuscle
  2. খ) Free nerve endings
  3. গ) Meissner corpuscle
  4. ঘ) Muscle spindle
সঠিক উত্তর:
খ) Free nerve endings
উত্তর
সঠিক উত্তর:
খ) Free nerve endings
৪১৭.
New olfactory area
  1. Hypothalamus
  2. Sepyal Nuclei
  3. Limbic System
  4. Orbitofrontal Cortex
সঠিক উত্তর:
Orbitofrontal Cortex
উত্তর
সঠিক উত্তর:
Orbitofrontal Cortex
৪১৮.
Vasogenic shock excludes
  1. ক) Septic shock
  2. খ) Surgical shock
  3. গ) Neurogenic shock
  4. ঘ) Anaphylactic shock
সঠিক উত্তর:
খ) Surgical shock
উত্তর
সঠিক উত্তর:
খ) Surgical shock
৪১৯.
Effect of exercise on cardiac output excludes
  1. ক) Positive chronotropism
  2. খ) Positive inotropism
  3. গ) Decrease venous return and thus stroke volume
  4. ঘ) Decrease in total peripheral resistance
সঠিক উত্তর:
গ) Decrease venous return and thus stroke volume
উত্তর
সঠিক উত্তর:
গ) Decrease venous return and thus stroke volume
ব্যাখ্যা

Explanation:
Effect of exercise on cardiac output
Exercise increase cardiac output and it is proportionate exercise intensity. The responses to exercise are:
• Positive chronotropism (i.e. increase heart rate)
• Positive inotropism (i.e. increase myocardial contractility)
• Increase venous return and thus stroke volume
• Decrease in total peripheral resistance

৪২০.
Which of the following hormone is called “Stress Hormone”?
  1. ক) PTH
  2. খ) Cortisol
  3. গ) Aldosterone
  4. ঘ) Thyroxin
সঠিক উত্তর:
খ) Cortisol
উত্তর
সঠিক উত্তর:
খ) Cortisol
ব্যাখ্যা
Cortisol is stress hormone
৪২১.
Ghrelin is released by the
  1. ক) Anterior pituitary gland
  2. খ) Stomach
  3. গ) Hypothalamus
  4. ঘ) D cell
সঠিক উত্তর:
খ) Stomach
উত্তর
সঠিক উত্তর:
খ) Stomach
ব্যাখ্যা
Ghrelin is released by the stomach.
৪২২.
A 32-year-old builder presents in accident and emergency in a distressed state. He reports suffering from chest pain for the last 2 weeks, the pain is sharp and only occurs when he moves heavy objects. He has a family history of cardiovascular disease and is worried about a heart attack. His blood gas findings are as follows: pH = 7.47; PCO2 = 3.3; PO2 = 15.3; bicarbonate = 17.53. The most likely diagnosis is:
  1. Respiratory acidosis with metabolic compensation
  2. Acute respiratory alkalosis
  3. Metabolic acidosis with respiratory compensation
  4. Acute metabolic acidosis
সঠিক উত্তর:
Acute respiratory alkalosis
উত্তর
সঠিক উত্তর:
Acute respiratory alkalosis
ব্যাখ্যা
The history in this case suggests the patient's chest pain is due to muscular injury rather than anything more sinister. The patient's anxiety about cardiovascular morbidity has ultimately resulted in hyperventilation causing an acute respiratory alkalosis . Acid base abnormalities can be solved by either considering the Henderson-Hasselbach equation (CO2 + H2O → H2CO3 → H+ + HCO3-), whereby change in the product(s) on one side of the equation is balanced by a shift in equilibrium. For example, in this case the patient's hyperventilation causes a reduction in CO2, in order to increase the CO₂ the equilibrium shifts towards CO₂ + H₂O which causes a reduction in H+ (alkalosis) and HCO3-. This process occurs in respiratory alkalosis with metabolic compensation (C). If the patient had a true cardiac arrest it would cause a surge in lactic acidosis hence H+ concentration increases causing a metabolic acidosis (B). In order to balance this change, the equilibrium shifts away from H+ and causes increased CO2 production which can manifest as an increased respiratory rate, otherwise called 'metabolic acidosis with respiratory compensation' (D). In a respiratory acidosis with metabolic compensation (A) scenario, a patient may have a respiratory abnormality such as chronic hypoventilation. The accumulation of CO2 which leads to increased H+ is compensated for by bicarbonate which is subsequently reduced. In more chronic conditions, the bicarbonate becomes elevated.
৪২৩.
Vit-k dependent blood clotting factors exclude:
  1. prothrombin
  2. Fibrinogen
  3. Factor lX
  4. Factor X
সঠিক উত্তর:
Fibrinogen
উত্তর
সঠিক উত্তর:
Fibrinogen
ব্যাখ্যা
Vit-k dependent blood clotting factors
 1. Factor ll(prothrombin)
2. Factor Vll
3. Factor IX  
4. Factor X
৪২৪.
The second heart sound is caused by
  1. closure of the aortic and pulmonary valves.
  2. vibrations in the ventricular wall during systole.
  3. ventricular filling
  4. closure of the mitral and tricuspid valves.
সঠিক উত্তর:
closure of the aortic and pulmonary valves.
উত্তর
সঠিক উত্তর:
closure of the aortic and pulmonary valves.
৪২৫.
Causes of eosinophilia:
  1. Prolong use of steroids
  2. Malaria
  3. Bone marrow disorder
  4. Polycythemia vera
সঠিক উত্তর:
Malaria
উত্তর
সঠিক উত্তর:
Malaria
৪২৬.
In clonus which of the following motor activity is increased?
  1. alpha
  2. beta
  3. gamma
  4. delta
সঠিক উত্তর:
gamma
উত্তর
সঠিক উত্তর:
gamma
৪২৭.
Types of RNA excludes:
  1. m RNA
  2. r RNA
  3. n RNA
  4. t RNA
সঠিক উত্তর:
n RNA
উত্তর
সঠিক উত্তর:
n RNA
ব্যাখ্যা
RNA three types

Messenger RNA , Ribosomal RNA, Transfer RNA
৪২৮.
At high altitude there is increase in
  1. pCO2
  2. pO2.
  3. Plasma HCO3
  4. Acidosis
সঠিক উত্তর:
Plasma HCO3
উত্তর
সঠিক উত্তর:
Plasma HCO3
৪২৯.
Highest oxygen consumption per 100 gm tissue
  1. Liver
  2. Kidney
  3. Brain
  4. Heart
সঠিক উত্তর:
Heart
উত্তর
সঠিক উত্তর:
Heart
৪৩০.
Incorrect about serum
  1. High level of serotonin
  2. Contain some degradation products of clotting factors
  3. Contains fibrinogen
  4. Can be obtained from clot retraction
সঠিক উত্তর:
Contains fibrinogen
উত্তর
সঠিক উত্তর:
Contains fibrinogen
ব্যাখ্যা
Explanations:
Serum contains no fibrinogen
৪৩১.
Root value of knee jerk
  1. ক) L2-L4
  2. খ) L2-L5
  3. গ) L5-S1
  4. ঘ) L5-S2
সঠিক উত্তর:
ক) L2-L4
উত্তর
সঠিক উত্তর:
ক) L2-L4
৪৩২.
Hormone act by cGMP mechanism
  1. ANP
  2. Angiotensin 2
  3. Calcitonin
  4. ADH
সঠিক উত্তর:
ANP
উত্তর
সঠিক উত্তর:
ANP
৪৩৩.
Normal quiet breathing is accomplished almost entirely by movement of the
  1. ক) Diaphragm
  2. খ) Internal intercostal muscle
  3. গ) External intercostal muscle
  4. ঘ) Rectus abdominis
সঠিক উত্তর:
ক) Diaphragm
উত্তর
সঠিক উত্তর:
ক) Diaphragm
ব্যাখ্যা
Reference: Guyton 14th; P- 491
৪৩৪.
Contraction of medial rectus helps in accommodation of eye by
  1. ক) Increasing anterior curvature of eyeball
  2. খ) Constriction of pupil
  3. গ) Dilatation of pupil
  4. ঘ) Convergence of eyeball
সঠিক উত্তর:
ঘ) Convergence of eyeball
উত্তর
সঠিক উত্তর:
ঘ) Convergence of eyeball
৪৩৫.
Cell membrane is semipermeable because of having
  1. Lipid
  2. Protein
  3. Carbohydrate
  4. Glycolipid
সঠিক উত্তর:
Protein
উত্তর
সঠিক উত্তর:
Protein
ব্যাখ্যা
Explanations:
The cell and the intracellular organelles are surrounded by semipermeable membranes. Biological membranes have a lipid bilayer core that is populated by structural and functional proteins. These proteins contribute greatly to the semipermeable properties of biological membrane.
৪৩৬.
Which is nuclear maturation defect anemia?
  1. IDA
  2. Thalassemia
  3. Hypersplenism
  4. Refractory anemia
সঠিক উত্তর:
Refractory anemia
উত্তর
সঠিক উত্তর:
Refractory anemia
৪৩৭.
Which promotes development of female breast & secretion of milk?
  1. Prolactin
  2. FSH
  3. LH
  4. Oxytocin
সঠিক উত্তর:
Prolactin
উত্তর
সঠিক উত্তর:
Prolactin
৪৩৮.
Dandy walker malforamtion is associated with
  1. 1st ventricle
  2. Lateral ventricle
  3. 3rd ventricle
  4. 4th ventricle
সঠিক উত্তর:
4th ventricle
উত্তর
সঠিক উত্তর:
4th ventricle
৪৩৯.
Clinical safe range of pH is
  1. 4.5-6
  2. 5.5-8
  3. 7-8
  4. 7.3-7.5
সঠিক উত্তর:
7.3-7.5
উত্তর
সঠিক উত্তর:
7.3-7.5
ব্যাখ্যা
Clinical safe range of pH is 7.3-7.5

ABC of Biochemistry 6th - P:342
৪৪০.
Slow fibre has
  1. An extensive sarcoplasmic reticu- lum
  2. Large amounts of glycolytic enzymes are present in slow fibers for rapid release of energy
  3. Have a less extensive blood supply
  4. More mitochondria
সঠিক উত্তর:
More mitochondria
উত্তর
সঠিক উত্তর:
More mitochondria
ব্যাখ্যা
Fast Fibers (Type II, White Muscle)
 The following are characteristics of fast fibers:
1. Fast fibers are large for great strength of contraction.
2. Fast fibers have an extensive sarcoplasmic reticulum for rapid release of calcium ions to initiate con- traction.
3. Large amounts of glycolytic enzymes are present in fast fibers for rapid release of energy by the glycolytic process.
4. Fast fibers have a less extensive blood supply than slow fibers because oxidative metabolism is of sec- ondary importance.
5. Fast fibers have fewer mitochondria than slow fibers, also because oxidative metabolism is secondary.
A deficit of red myoglobin in fast muscle gives it the name white muscle.
৪৪১.
During normal quiet respiration---------------------of the total energy expended by the body is required for pulmonary ventilation.
  1. only 1% to 2%
  2. only 2% to 3%
  3. only 3% to 5%
  4. only 5% to 8%
সঠিক উত্তর:
only 3% to 5%
উত্তর
সঠিক উত্তর:
only 3% to 5%
ব্যাখ্যা
Energy Required for Respiration.
During normal quiet respiration, only 3% to 5% of the total energy expended by the body is required for pulmonary ventilation. However, during heavy exercise, the amount of energy required can increase as much as 50-fold, especially if the person has any degree of increased airway resistance or decreased pulmo- nary compliance. Therefore, one of the major limitations on the intensity of exercise that can be performed is the person's ability to provide enough muscle energy for the respiratory process alone.
৪৪২.
Excess Catecholamine causes-
  1. ক) Phenylketonuria
  2. খ) Phaeochromocytoma
  3. গ) Parinaud syndrome
  4. ঘ) Parkinson disease
সঠিক উত্তর:
খ) Phaeochromocytoma
উত্তর
সঠিক উত্তর:
খ) Phaeochromocytoma
ব্যাখ্যা
Phaeochromocytoma is a catecholamine secreting tumor.
৪৪৩.
Multiple myeloma is associated with
  1. Overproduction of IgG
  2. Peripheral blood smear shows rouleaux formation
  3. Bone marrow analysis shows > 10% monoclonal plasma cells
  4. All
সঠিক উত্তর:
All
উত্তর
সঠিক উত্তর:
All
৪৪৪.
Ep is used in
  1. CKD
  2. Dialysis Patients
  3. During elective surgery
  4. All
সঠিক উত্তর:
All
উত্তর
সঠিক উত্তর:
All
ব্যাখ্যা
Erythropoietin is produced by interstitial cells in the peritubular capillary bed of the kidneys and by perivenous hepatocytes in the liver. It is also produced in the brain, where it exerts a protective effect against excitotoxic damage triggered by hypoxia; and in the uterus and oviducts, where it is induced by estrogen and appears to mediate estrogen-dependent angiogenesis.
The gene for the hormone has been cloned, and recombinant erythropoietin produced in animal cells is available for clinical use as epoetin alfa.
The recombinant erythropoietin is of value in the treatment of the anemia associated with kidney failure; 90% of the patients with end-stage renal disease who are undergoing dialysis are anemic as a result of erythropoietin deficiency. Erythropoietin is also used to stimulate red cell production in individuals who are banking a supply of their own blood in preparation for autologous transfusions during elective surgery (see Chapter 31).
৪৪৫.
Cell membrane is semipermeable because of having
  1. ক) Lipid
  2. খ) Protein
  3. গ) Carbohydrate
  4. ঘ) Glycolipid
সঠিক উত্তর:
খ) Protein
উত্তর
সঠিক উত্তর:
খ) Protein
ব্যাখ্যা
Explanations:
The cell and the intracellular organelles are surrounded by semipermeable membranes. Biological membranes have a lipid bilayer core that is populated by structural and functional proteins. These proteins contribute greatly to the semipermeable properties of biological membrane.
৪৪৬.
Hematopoietic function of cortisol is to increase count of
  1. Eosinophil
  2. Lymphocyte
  3. erythrocyte
  4. basophil
সঠিক উত্তর:
erythrocyte
উত্তর
সঠিক উত্তর:
erythrocyte
ব্যাখ্যা
Hematopoietic function of cortisol
·         BEL ↓ (basophil, Eosinophil, Lymphocyte)

·         PEN ↑ (Platelet, erythrocyte, neutrophil)
৪৪৭.
Which cell of the pancreas secrets amylin
  1. Alpha
  2. Beta
  3. Delta
  4. Pancreatic Pol
সঠিক উত্তর:
Beta
উত্তর
সঠিক উত্তর:
Beta
৪৪৮.
Stimuli that inhibit gastrin secretion
  1. ক) Somatostatin
  2. খ) Distention
  3. গ) Increased vagal discharge
  4. ঘ) Calcium
সঠিক উত্তর:
ক) Somatostatin
উত্তর
সঠিক উত্তর:
ক) Somatostatin
ব্যাখ্যা
Somatostatin inhibits gastrin secretion.
৪৪৯.
Which of the following is the site of Na+–bile acid cotransport?
  1. ক) Gastric antrum
  2. খ) Gastric fundus
  3. গ) Duodenum
  4. ঘ) Ileum
সঠিক উত্তর:
ঘ) Ileum
উত্তর
সঠিক উত্তর:
ঘ) Ileum
ব্যাখ্যা
Explanation-
★Bile salts are recirculated to the liver in the enterohepatic circulation via a Na+–bile acid cotransporter located in the ileum of the small intestine.
Reference-BRS physiology/6th/P-212/Fig-6.12
৪৫০.
Pathological causes of sinus bradycardia exclude
  1. ক) Pregnancy
  2. খ) Hypothyroidism
  3. গ) Myocardial infraction
  4. ঘ) Raised intracranial pressure
সঠিক উত্তর:
ক) Pregnancy
উত্তর
সঠিক উত্তর:
ক) Pregnancy
ব্যাখ্যা

Explanation:
Pathological causes of sinus bradycardia
• Hypothermia
• Hypothyroidism
• Myocardial infraction
• Raised intracranial pressure
• Cholestatic jaundice
• Drugs (beta-blockers, digoxin, antiarrhythmic drugs)

৪৫১.
A raised blood pH & Bicarbonate level is consistent with-?
  1. ক) Persistant vomiting of gastric content
  2. খ) Chronic renal failure with raised PC02
  3. গ) A reduced PCO2
  4. ঘ) Partly compensated respiratory alkalosis
সঠিক উত্তর:
ক) Persistant vomiting of gastric content
উত্তর
সঠিক উত্তর:
ক) Persistant vomiting of gastric content
ব্যাখ্যা

Metabolic effects of prolonged vomiting are-
-Metabolic alkalosis
-Hypovolemia leading to lactic acidosis
-Hypokalemia
-Hypochloremia
-Paradoxical aciduria
-Compensatory hypoventilation

৪৫২.
Following which is most important control system under negative feedback mechanism-?
  1. ক) Blood clotting
  2. খ) LH surge.
  3. গ) Regulation of water balance
  4. ঘ) Blood pressure control system
সঠিক উত্তর:
ঘ) Blood pressure control system
উত্তর
সঠিক উত্তর:
ঘ) Blood pressure control system
ব্যাখ্যা
Blood pressure regulation is the most important Which is regulated by negative feedback mechanism.
৪৫৩.
A 56-year-old man, diagnosed with emphysema, presents with a one-month history of jaundice and ascites. Your registrar suspects that this patient may have liver disease secondary to a₁-antitrypsin deficiency. Select the most likely mode of inheritance from the list below:
  1. Autosomal dominant
  2. X-linked dominant
  3. Autosomal recessive
  4. Polygenic
সঠিক উত্তর:
Autosomal recessive
উত্তর
সঠিক উত্তর:
Autosomal recessive
ব্যাখ্যা
a₁-antitrypsin deficiency is an autosomal recessive disorder (C), which results from single amino acid substitutions at positions 264 and 342 on chromosome 14. ₁-antitrypsin is a serine protease, synthesized in the liver, required in controlling inflammatory cascades. The lack of this serine protease results in emphysema (75 per cent), chronic liver disease and hepatocellular carcinoma, asthma, pancreatitis, gallstones, Wegener's granulomatosis.
Patients with liver disease secondary to d₁-antitrypsin deficiency usually present with dyspnoea (from emphysema), liver cirrhosis, cholestatic jaundice. Investigations include: serum a₁-antitrypsin levels, liver biopsy, genetic phenotyping and DNA analysis at prenatal diagnosis. Management involves quitting smoking, augmentation therapy with α₁-antitrypsin pooled from human plasma and liver transplantation is the treatment of choice in decompensated cirrhosis.
৪৫৪.
Erythropoietin is secreted by-?
  1. ক) cells in the proximal tubules.
  2. খ) cells in the distal tubules.
  3. গ) granular cells in the juxtaglomerular apparatus.
  4. ঘ) Cells in the peritubular capillary bed.
সঠিক উত্তর:
ঘ) Cells in the peritubular capillary bed.
উত্তর
সঠিক উত্তর:
ঘ) Cells in the peritubular capillary bed.
ব্যাখ্যা
Erythropoietin is produced by interstitial cells in the peritubular capillary bed of the kidneys and by perivenous hepatocytes in the liver.
৪৫৫.
Fructose as a component of semen if derived from secretion of
  1. Prostate
  2. Seminal vesicle
  3. Urethra
  4. Ejaculatory duct
সঠিক উত্তর:
Seminal vesicle
উত্তর
সঠিক উত্তর:
Seminal vesicle
৪৫৬.
Not correct about Graves’ disease
  1. Goiter with bruit
  2. Corneal xerosis
  3. Retraction of upper eye lid, lid lag
  4. Digital clubbing
সঠিক উত্তর:
Corneal xerosis
উত্তর
সঠিক উত্তর:
Corneal xerosis
ব্যাখ্যা
Graves’ disease
Definition: It is an autoimmune disease in which circulating antibodies are formed against the TSH receptor and activates the thyroid gland hyperactive, resulting in development of goiter and hypersecretion of T3 & T4
More common in women

Clinical features:
1.  Goiter with bruit
2.  Exophthalmos-protrusion of the eye ball (it is the hallmark of Graves' disease)
3.  Retraction of upper eye lid, lid lag
4.  Corneal ulceration
5.  Diplopia
6.  Ophthalmoplegia
7.  Papilledema
8.  Loss of visual acuity
9.  Vitiligo
10.  Digital clubbing
11.  Pretibial myxedema

 
৪৫৭.
A 58-year-old man has made an excellent functional recovery after an anterior MI. He is entirely asymptomatic and there is no abnormality on physical examination. His blood pressure is 134/78 mmHg and he is undertaking a cardiac rehabilitation programme. Which of the following would you not recommend as part of his secondary prevention planning?
  1. Aspirin
  2. Simvastatin
  3. Omega-3 fatty acids
  4. Bisoprolol
সঠিক উত্তর:
Omega-3 fatty acids
উত্তর
সঠিক উত্তর:
Omega-3 fatty acids
ব্যাখ্যা
There is strong clinical trial evidence for the other four classes of drugs (A-D), although it is not clear how long the duration of therapy should be in each case. This benefit is applicable to normotensive patients with 'normal' LDL levels, although what constitutes normal in this case is controversial. Targets are likely to be reduced in the near future. One clinical trial did appear to shown additional benefit for the omega-3 fatty acids  this was in a population where few were receiving statins. Subsequent data have not supported their routine use.
৪৫৮.
TCA cycle is inhibited by
  1. NAD
  2. Citrate
  3. Insulin
  4. ADP
সঠিক উত্তর:
Citrate
উত্তর
সঠিক উত্তর:
Citrate
ব্যাখ্যা
ABC of Biochemistry 6th - P: 152


TCA cycle
Inhibition- ATP, NADH, Citratrate
Stimulation- ADP, NAD,Insulin
৪৫৯.
Fluid output through sweat (ml) in normal condition?
  1. ক) 100
  2. খ) 200
  3. গ) 350
  4. ঘ) 500
সঠিক উত্তর:
ক) 100
উত্তর
সঠিক উত্তর:
ক) 100
৪৬০.
Inhibitory neurotransmitter
  1. ক) Acetylcholine
  2. খ) Histamine
  3. গ) GABA
  4. ঘ) NO
সঠিক উত্তর:
গ) GABA
উত্তর
সঠিক উত্তর:
গ) GABA
৪৬১.
Can be measured by spirometry
  1. ক) Vital capacity
  2. খ) Residual volume
  3. গ) Functional residual volume
  4. ঘ) Total lung capacity
সঠিক উত্তর:
ক) Vital capacity
উত্তর
সঠিক উত্তর:
ক) Vital capacity
ব্যাখ্যা
Volume, which cannot be measured by spirometry, is the residual volume. Capacities, which include residual volume also cannot be measured. Capacities that include residual volume are functional residual capacity and total lung capacity.
৪৬২.
Longest Part of Nephron
  1. Loop of Henle
  2. DCT
  3. PCT
  4. CD
সঠিক উত্তর:
PCT
উত্তর
সঠিক উত্তর:
PCT
৪৬৩.
Thyroglobulin precursor is secreted from
  1. ক) RER
  2. খ) SER
  3. গ) Golgi apparatus
  4. ঘ) Lysosome
সঠিক উত্তর:
গ) Golgi apparatus
উত্তর
সঠিক উত্তর:
গ) Golgi apparatus
৪৬৪.
RV=?
  1. 1200 ml
  2. 1100ml
  3. 4600 ml
  4. 5800 ml
সঠিক উত্তর:
1200 ml
উত্তর
সঠিক উত্তর:
1200 ml
ব্যাখ্যা
Guyton  13th-501-502
৪৬৫.
Total lung capacity (ml) in women
  1. 5600
  2. 5800
  3. 4200
  4. 4600
সঠিক উত্তর:
4200
উত্তর
সঠিক উত্তর:
4200
ব্যাখ্যা
Reference: Guyton 14th; P- 495
৪৬৬.
The ultimate goal of respiration is to maintain proper concentrations of the following in the tissues except?
  1. O2
  2. CO2
  3. HCO3-
  4. H+
সঠিক উত্তর:
HCO3-
উত্তর
সঠিক উত্তর:
HCO3-
ব্যাখ্যা
Reference: Guyton 14th; P- 533
৪৬৭.
Complete hemolysis of RBC occur at.. .% NaCl solution
  1. 0.33
  2. 0.45
  3. 0.9
  4. 3
সঠিক উত্তর:
0.33
উত্তর
সঠিক উত্তর:
0.33
৪৬৮.
Which is not a Nonspecific laboratory findings associated with hyperthyroidism.
  1. Increased serum total cholesterol and LDL-C
  2. Increased TAG (Triacyl glycerol)
  3. Hyponatremia
  4. Increased ALT
সঠিক উত্তর:
Increased ALT
উত্তর
সঠিক উত্তর:
Increased ALT
ব্যাখ্যা
  Nonspecific laboratory findings associated with hypothyroidism.
Ø  Increased serum total cholesterol and LDL-C

Ø  Increased TAG (Triacyl glycerol)

Ø  Hyponatremia (due to free water retention)

Ø  Increased CPK (due to myopathy)
৪৬৯.
Synthesis of Hb starts from
  1. ক) Proerythroblast
  2. খ) Early normoblast
  3. গ) Intermediate normoblast
  4. ঘ) Reticulocyte
সঠিক উত্তর:
ক) Proerythroblast
উত্তর
সঠিক উত্তর:
ক) Proerythroblast
৪৭০.
How to perform an oral glucose tolerance test (OGTT)
  1. restricted carbohydrate diet for 3 days
  2. Fasted overnight for at least 18 hrs
  3. Walk for 30 mins
  4. Plasma glucose is measured before and 2 hrs after a 75 g oral glucose drink
সঠিক উত্তর:
Plasma glucose is measured before and 2 hrs after a 75 g oral glucose drink
উত্তর
সঠিক উত্তর:
Plasma glucose is measured before and 2 hrs after a 75 g oral glucose drink
ব্যাখ্যা
How to perform an oral glucose tolerance test (OGTT)
Preparation before the test
·       Unrestricted carbohydrate diet for 3 days
·       Fasted overnight for at least 8 hrs
·       Rest for 30 mins
·       Remain seated for the duration of the test, with no smoking
৪৭১.
Neuromodulator of basal ganglia
  1. GABA
  2. Dopamine
  3. Glycine
  4. Ach
সঠিক উত্তর:
Ach
উত্তর
সঠিক উত্তর:
Ach
৪৭২.
Factors that shift 02-Hb dissociation curve to left
  1. ক) Increased pH
  2. খ) Increased CO2
  3. গ) Increased temperature
  4. ঘ) Increased BPG
সঠিক উত্তর:
ক) Increased pH
উত্তর
সঠিক উত্তর:
ক) Increased pH
ব্যাখ্যা
Reference: Guyton 14th; P- 526
৪৭৩.
When RBC is into Hypertonic Solution following shape is found
  1. Crenation
  2. Sickle cell
  3. Poikilocytosis
  4. Eliptocytosis
সঠিক উত্তর:
Crenation
উত্তর
সঠিক উত্তর:
Crenation
৪৭৪.
A raised blood pH & Bicarbonate level is consistent with-?
  1. ক) Persistent vomiting of gastric content
  2. খ) Chronic renal failure with raised PC02
  3. গ) Partly compensated respiratory alkalosis
  4. ঘ) Metabolic acidosis
সঠিক উত্তর:
ক) Persistent vomiting of gastric content
উত্তর
সঠিক উত্তর:
ক) Persistent vomiting of gastric content
ব্যাখ্যা

Metabolic effects of prolonged vomiting are-
-Metabolic alkalosis
-Hypovolemia leading to lactic acidosis
-Hypokalemia
-Hypochloremia
-Paradoxical aciduria
-Compensatory hypoventilation

৪৭৫.
The Permissive action of cortisol is on-
  1. ক) Thyroxine
  2. খ) Aldosterone
  3. গ) Glucagon
  4. ঘ) Growth hormone
সঠিক উত্তর:
গ) Glucagon
উত্তর
সঠিক উত্তর:
গ) Glucagon
ব্যাখ্যা
The Permissive action of cortisol is on glucagon
৪৭৬.
Standard scale to measure Plasma Bicarbonate Conc
  1. Temp 37 C
  2. Venous PCO2 40 mmHg
  3. Hb Conc 15 mg/dl
  4. O2 saturation 94%
সঠিক উত্তর:
Temp 37 C
উত্তর
সঠিক উত্তর:
Temp 37 C
ব্যাখ্যা
ABC of Biochemistry 6th - P: 352
৪৭৭.
Maximum CO2 is transported as
  1. ক) Dissolved state
  2. খ) HCO3-
  3. গ) Hb-CO2
  4. ঘ) H2CO3
সঠিক উত্তর:
খ) HCO3-
উত্তর
সঠিক উত্তর:
খ) HCO3-
ব্যাখ্যা
Reference: Guyton 14th; P- 528
৪৭৮.
Lesion of left optic nerve results in
  1. ক) Total blindness of left eye
  2. খ) Total blindness of right eye
  3. গ) Left homonymous hemianopia
  4. ঘ) Right homonymous hemianopia
সঠিক উত্তর:
ক) Total blindness of left eye
উত্তর
সঠিক উত্তর:
ক) Total blindness of left eye
৪৭৯.
Specific gravity of urine is low in
  1. DM
  2. DI
  3. CRF
  4. AKI
সঠিক উত্তর:
DI
উত্তর
সঠিক উত্তর:
DI
ব্যাখ্যা
Specific gravity of urine is the measure of dissolved solutes (particles) in urine. It is low in diabetes insipidus and high in diabetes mellitus, acute renal failure and excess medications.
৪৮০.
Autoregulation range of RBF is
  1. below 80 mmHg
  2. above 180 mm Hg
  3. 80/120 mmHg
  4. 80-180 mmHg
সঠিক উত্তর:
80-180 mmHg
উত্তর
সঠিক উত্তর:
80-180 mmHg
৪৮১.
Which of the following does not support accommodation reflex?
  1. ক) Contraction of medial recti
  2. খ) Relaxation of the ciliary muscle
  3. গ) Contraction of constrictor pupillae of iris
  4. ঘ) Increase in the anterior curvature of the lens
সঠিক উত্তর:
খ) Relaxation of the ciliary muscle
উত্তর
সঠিক উত্তর:
খ) Relaxation of the ciliary muscle
ব্যাখ্যা
Explanation : Accommodation is a reflex action. When a person looks at a near object after seeing a far object, three adjustments are made in the eyeballs:
1. Convergence of the eyeballs due to contraction of the medial recti
2. Constriction of the pupil due to the contraction of constrictor pupillae of iris
3. Increase in the anterior curvature of the lens due to contraction of the ciliary muscle.
Ref : Sembulingam 6th edition (Page- 997)
৪৮২.
Which acts as final common path of cerebellar cortex?
  1. ক) Stellate cell
  2. খ) Basket cell
  3. গ) Purkinje cell
  4. ঘ) Golgi cell
সঠিক উত্তর:
গ) Purkinje cell
উত্তর
সঠিক উত্তর:
গ) Purkinje cell
ব্যাখ্যা
Explantion : Purkinje cells are termed as ‘final common path’ of cerebellar cortex. It is because the impulses from different parts of cerebellar cortex are transmitted to other parts of brain only through Purkinje cells.
Ref : Sembulingam 6th edition (Page- 866)
৪৮৩.
Which lens is used in myopia?
  1. ক) Biconcave
  2. খ) Biconvex
  3. গ) Cylindrical
  4. ঘ) Both biconcave & biconvex
সঠিক উত্তর:
ক) Biconcave
উত্তর
সঠিক উত্তর:
ক) Biconcave
৪৮৪.
Port Wine birthmark is present in
  1. Lateral Medullary syndrome
  2. Medial Medullary syndrome
  3. Weber Syndrome
  4. Claude syndrome
সঠিক উত্তর:
Weber Syndrome
উত্তর
সঠিক উত্তর:
Weber Syndrome
৪৮৫.
Which of the following hormone is called “Life Saving Hormone”?
  1. ক) ADH
  2. খ) Aldosterone
  3. গ) Cortisol
  4. ঘ) Insulin
সঠিক উত্তর:
খ) Aldosterone
উত্তর
সঠিক উত্তর:
খ) Aldosterone
ব্যাখ্যা
Aldosterone is life saving hormone
৪৮৬.
Sky rise of ESR is found in
  1. ক) Polycythaemia vera
  2. খ) Pregnancy
  3. গ) Giant cell arteritis
  4. ঘ) MI
সঠিক উত্তর:
গ) Giant cell arteritis
উত্তর
সঠিক উত্তর:
গ) Giant cell arteritis
ব্যাখ্যা

Explanations:
ESR>100 is regarded as sky rise. It occurs in
• Multiple myeloma
• Giant cell arteritis
• Severe infections
• Malignancy

৪৮৭.
Which one is reduced in anaemic hypoxia?
  1. ক) PO2
  2. খ) O2 carrying capacity
  3. গ) Velocity of blood
  4. ঘ) Utilization of O2 by tissues
সঠিক উত্তর:
খ) O2 carrying capacity
উত্তর
সঠিক উত্তর:
খ) O2 carrying capacity
ব্যাখ্যা
Explanation:
৪৮৮.
Lifespan of RBCs:
  1. 90 days
  2. 120 days
  3. 4 days
  4. 10 days
সঠিক উত্তর:
120 days
উত্তর
সঠিক উত্তর:
120 days
৪৮৯.
The most active adrenal androgen is
  1. ক) Dehydroepiandrosterone
  2. খ) Androstenedione
  3. গ) Testosterone
  4. ঘ) Cortisol
সঠিক উত্তর:
ক) Dehydroepiandrosterone
উত্তর
সঠিক উত্তর:
ক) Dehydroepiandrosterone
ব্যাখ্যা

Androgens secreted by adrenal cortex:
 Dehydroepiandrosterone
 Androstenedione
 Testosterone
Dehydroepiandrosterone is the most active adrenal androgen.

৪৯০.
Highest Energy Expenditure During Different Types of Activity for a 70-Kilogram Person Form of Activity Calories per Hour
  1. Sawing wood
  2. Swimming
  3. Running (5.3 miles per hour)
  4. Walking up stairs rapidly
সঠিক উত্তর:
Walking up stairs rapidly
উত্তর
সঠিক উত্তর:
Walking up stairs rapidly
৪৯১.
Accessory digestive organs exclude
  1. ক) Teeth
  2. খ) Tongue
  3. গ) Pharynx
  4. ঘ) Salivary glands
সঠিক উত্তর:
গ) Pharynx
উত্তর
সঠিক উত্তর:
গ) Pharynx
ব্যাখ্যা

Accessory digestive organs are those which help primary digestive organs in the process of digestion. Accessory digestive organs are:
• Teeth
• Tongue
• Salivary glands
• Exocrine part of pancreas
• Liver
• Gallbladder

৪৯২.
In smooth muscle calcium released by the smooth ER initiates contraction by binding to what protein?
  1. ক) Actin
  2. খ) Calmodulin
  3. গ) Desmin
  4. ঘ) Myosin light chain kinase
সঠিক উত্তর:
খ) Calmodulin
উত্তর
সঠিক উত্তর:
খ) Calmodulin
ব্যাখ্যা
[Ganong 24th p-115]
৪৯৩.
What is the resting membrane potential of a nerve fibre?
  1. ক) -90 mV
  2. খ) -70 mV
  3. গ) -55 mV
  4. ঘ) =+35 mV
সঠিক উত্তর:
খ) -70 mV
উত্তর
সঠিক উত্তর:
খ) -70 mV
ব্যাখ্যা

Ref : Sembulingam 6th edition (Table- 136.1)
Explanation : RMP of a nerve fibre is -70 mV, Firing level of a nerve fibre is -55 mv, End of depolarization of the nerve fibre is at +35 mV.

Ref : Sembulingam 6th edition (Table- 136.1)
৪৯৪.
FRC in women
  1. 1800
  2. 2400
  3. 3100
  4. 4200
সঠিক উত্তর:
1800
উত্তর
সঠিক উত্তর:
1800
৪৯৫.
Severe Hypotonicity of ECF compared to ICF may lead to-?
  1. ক) Cellular overhydration
  2. খ) Cerebral oedema
  3. গ) Cellular dehydration
  4. ঘ) Hyperkalemia
সঠিক উত্তর:
খ) Cerebral oedema
উত্তর
সঠিক উত্তর:
খ) Cerebral oedema
ব্যাখ্যা
Reference-Davidson/23rd/P-435/Fig-16.6
৪৯৬.
Regarding inhibin which is not suited
  1. They are formed from two polypeptide subunits
  2. Inhibins are produced by Sertoli cells in males
  3. Inhibin extracts from antral fluid from ovarian follicles in women
  4. Inhibins are produced by granulosa cells in females.
সঠিক উত্তর:
They are formed from two polypeptide subunits
উত্তর
সঠিক উত্তর:
They are formed from two polypeptide subunits
৪৯৭.
Which of the followings is false regarding accommodation reflex?
  1. ক) Increases the visual acuity
  2. খ) Reduces lateral chromatic aberrations
  3. গ) Increases spherical aberrations
  4. ঘ) Increases the depth of focus
সঠিক উত্তর:
গ) Increases spherical aberrations
উত্তর
সঠিক উত্তর:
গ) Increases spherical aberrations
ব্যাখ্যা
Explanation : In addition to increase in anterior curvature of the lens, two more adjustments are made in the eyeball during accommodation for near vision.
1. Convergence of both eyeballs: It is necessary to bring the retinal images on to the corresponding points
2. Constriction of pupil: It is necessary to:
i. Increase the visual acuity by reducing lateral chromatic and spherical aberrations
ii. Reduce the quantity of light entering eye
iii. Increase the depth of focus through more central part of lens as its convexity is increased.
Ref : Sembulingam 6th edition (Page- 996)
৪৯৮.
Co factor of carboxy peptidase
  1. Cu
  2. Mg
  3. Iron
  4. Zn
সঠিক উত্তর:
Zn
উত্তর
সঠিক উত্তর:
Zn
৪৯৯.
Calculate HCO3 space in a 70 kg man when HCO3 conc 24 mmol/l
  1. 33
  2. 32
  3. 31
  4. 40
সঠিক উত্তর:
32
উত্তর
সঠিক উত্তর:
32
ব্যাখ্যা
HCOspace= (0.36+ 2.44/HCO3 conc) * BW

ABC of Biochemistry 6th - P:352
৫০০.
Which is not a protopathic sensation?
  1. ক) Kinesthetic sensation
  2. খ) Pressure sensation
  3. গ) Pain sensation
  4. ঘ) Temparature sensation with wider range
সঠিক উত্তর:
ক) Kinesthetic sensation
উত্তর
সঠিক উত্তর:
ক) Kinesthetic sensation
ব্যাখ্যা
Explanation : Pressure sensation,pain sensation,temparature sensation with wider range (below 25 degree celcius & above 40 degree celcius) are protopathic sensation. Epicritic sensations are: i. Fine touch or tactile sensation, ii. Tactile localization, iii. Tactile discrimination, iv. Temperature sensation with finer range between 25°C and 40°C.Visceral,vibratory & kinesthetic sensations are deep sensations.
Ref : Sembulingam 6th edition (Figure- 144.1)