Bleeding Disorders

Explanation: coagulation screening tests are Platelet count, PT, APTT & Fibrinogen concentration

Ref: Davidson 23rd; P-928, box: 23.13

Haemorrhagic disease of the newborn: Haemorrhagic disease of the newborn: enzyme-inducing antiepileptic drugs increase risk. Give IM vitamin K (1 mg) to the infant at birth.

Explanation: Factor VIII deficiency resulting in haemophilia A affects 1/10 000 individuals. It is the most common congenital coagulation factor deficiency

Reference: Davidson 23rd, Box-3.4

Explanation: Factor V Leiden mutation is the most common inherited thrombophilia. Davidson explains that this mutation renders Factor V resistant to inactivation by activated protein C, leading to a prothrombotic state. Harrison discusses that individuals with Factor V Leiden have a higher risk of venous thromboembolism, particularly in the presence of additional risk factors like surgery or immobility.

Ref: Davidson 23rd; P-971

TP is characterised by a pentad of findndings, although few patients have all five components:
 thrombocytopenia  microangiopathic haemolytic anaemia  neurological sequelae  fever  renal impairmen

Innhibition of post-translational modification: Warfarin

Ref: Davidson 23rd; P-974

Ref: Davidson 23rd; P-971