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Autoimmunity

মোট প্রশ্ন২৯এই পাতা২৯প্রতি পাতা১০০
প্রশ্ন দেখুনঅনুশীলন
ঘনত্ব
উত্তর
উত্তরিতবর্তমানপুনরায় দেখুনঅসম্পূর্ণ

Autoimmunity

PrepBank · পাতা ১ / ১ · ১–২৯ / ২৯

১.
Campylobacter jejuni infection have been linked to
  1. ক
    ক) Gas gangrene
  2. খ
    খ) Myocarditis
  3. গ
    গ) GBS
  4. ঘ
    ঘ) Inflammatory bowel disease
ব্যাখ্যা
Explanation: Campylobacter species have been linked to GBS & post infectious reactive arthritis.
২.
Which disease mostly affect sacroiliac joint -
  1. ক
    Psoriatic arthritis
  2. খ
    Rheumatoid arthritis
  3. গ
    SLE
  4. ঘ
    Ankylosing spondylitis
ব্যাখ্যা
Explanation :
Ankylosing spondylitis involve mostly sacroiliac joint and vertebra.
৩.
Psoriatic arthopathy -
  1. ক
    Asymmetrical inflammatory oligoarthritis
  2. খ
    Ankle joint involved
  3. গ
    CRP normal
  4. ঘ
    Skip lesion
ব্যাখ্যা
Explanation :
Psoriatic arthritis is a type of arthritis linked with psoriasis, a chronic skin and nail disease. Psoriasis causes red, scaly rashes and thick, pitted fingernails.
Mostly distal interphaleangeal joint involved
৪.
Not the feature of SLE -
  1. ক
    Discoid rash
  2. খ
    Tenosynuvitis
  3. গ
    Serositis
  4. ঘ
    Oral ulcer
৫.
ANA is 100% sensitive for which of the following disease?
  1. ক
    ক) Systemic sclerosis
  2. খ
    খ) Dermatomyositis
  3. গ
    গ) Rheumatoid arthritis
  4. ঘ
    ঘ) SLE
ব্যাখ্যা
Explanation: ANA is 100% sensitive for Systemic lupus erythematosus, Autoimmune hepatitis and Mixed connective tissue disease
৬.
Which is not the extrarticular features of rheuratoid arthritis -
  1. ক
    Fever
  2. খ
    Felty syndrome
  3. গ
    Episcleritis
  4. ঘ
    Urethritis
৭.
Which is not the extra articular feature of reactive arthritis -
  1. ক
    Circinate balanitis
  2. খ
    Ketatoderma blennorrhagica
  3. গ
    Buccal erosions
  4. ঘ
    Haematuria
ব্যাখ্যা
Explanation -
Extraarticular features of reactive arthritis -
Circinate balanitis
Keratoderma blennorrhagica
Nail dystrophy
Buccal erosions
৮.
Radiographic hallmarks in RA excludes
  1. ক
    ক) Joint effusions
  2. খ
    খ) Juxta-articular osteopenia with erosions
  3. গ
    গ) Widening of the joint space
  4. ঘ
    ঘ) Loss of articular cartilage
ব্যাখ্যা

Radiographic hallmarks are
 Joint effusions
 Juxta-articular osteopenia with erosions
 Narrowing of the joint space
 Loss of articular cartilage

৯.
Not true about JIA
  1. ক
    ক) Oligoarthritis is more common,
  2. খ
    খ) Large joints are affected more often than small joints,
  3. গ
    গ) Rheumatoid nodules and rheumatoid factor are usually present
  4. ঘ
    ঘ) Antinuclear antibody (ANA) seropositivity is common.
ব্যাখ্যা
• Oligoarthritis is more common,
• Systemic disease is more frequent,
• Large joints are affected more often than small joints,
• Rheumatoid nodules and rheumatoid factor are usually absent, and
• Antinuclear antibody (ANA) seropositivity is common.
১০.
Which immune cell is initiate autoimmune reaction in rheumatoid arthritis -
  1. ক
    NK cell
  2. খ
    CD4 + T lymphocyte
  3. গ
    CD8 + T lymphocyte
  4. ঘ
    Macrophage
ব্যাখ্যা
Explanation :
CD4 + T helper cells may initiate the autoimmune response in RA by reacting arthritogenic agent.
১১.
Criteria oaf arthritis in SLE excludes
  1. ক
    ক) Symmetrical
  2. খ
    খ) Mechanical
  3. গ
    গ) Principally affects small joint
  4. ঘ
    ঘ) Joints of hands & feet are involved
ব্যাখ্যা
• RA typically manifests as a symmetric arthritis principally affecting the small joints of the hand and feet.
১২.
Guillain Barre syndrome -
  1. ক
    Disease of CNS
  2. খ
    Related to desending paralysis
  3. গ
    2/3rd cases recovered spontaneously
  4. ঘ
    Chronic inflammatory demyelinating polyneuropathy
ব্যাখ্যা
Explanation :
Guillain Barre syndrome ( Acute inflammatory demyelinating polyneuropathy) 
Causing ascending paralysis
Disease of perpheral nervous system.
১৩.
Coombs test is used for detecting -
  1. ক
    Haemolytic autoantibody
  2. খ
    Fetal aneuploidy
  3. গ
    Antigen detection
  4. ঘ
    Hepatitis B viral DNA
ব্যাখ্যা
Explanation :
Direct coombs test - Haemolytic autoantibody 
Indirect coombs test -
Rh antibody.
১৪.
Radiographic abnormalities of Rheumatoid arthritis is
  1. ক
    ক) Osteophytes
  2. খ
    খ) Joint space narrowing
  3. গ
    গ) Subchondral sclerosis
  4. ঘ
    ঘ) Joint deformity
ব্যাখ্যা

Radiographic abnormalities of Rheumatoid arthritis are:
 Periarticular osteoporosis
 Marginal joint erosions
 Joint subluxation
 Joint space narrowing

১৫.
Which is not seronegetive arthopathy -
  1. ক
    Psoriatic arthopathy
  2. খ
    Reactive arthritis
  3. গ
    Juvenile idiopathic arthritis
  4. ঘ
    Enteropathic arthritis
ব্যাখ্যা
Explanation :
Seronegetive arthritis -
Reactive arthritis
Psoriatic arthritis
Ankylosing spondylitis
Enteropathic arthritis
১৬.
Hallmark of SLE
  1. ক
    ক) Female predominant
  2. খ
    খ) Joint involvement
  3. গ
    গ) Skin rash
  4. ঘ
    ঘ) Production of autoantibodies
ব্যাখ্যা
The hallmark of SLE is the production of autoantibodies Antibodies to double-stranded DNA and the so-called Smith (Sm) antigen are virtually diagnostic of SLE.
১৭.
Which is not clinical triad of Grave's disease -
  1. ক
    Goiter
  2. খ
    Ophthalmoplagia
  3. গ
    Exophthalmos
  4. ঘ
    Pretibial myxoedema
ব্যাখ্যা
Explanation :
Clinical triad of Grave's disease :
Goiter
Exophthalmos
Pretibial myxoedema
১৮.
Rhematoid arthritis -
  1. ক
    Male : Female = 1:3
  2. খ
    No muscle wasting
  3. গ
    Age 2nd decade
  4. ঘ
    Thrombocytopenia present
ব্যাখ্যা
Explanation :
Rheumatoid arthritis :
Affect 3rd to 5th decade
Male : Female - 1:5
Anaemia present
Limitation of movement and muscle wasting
১৯.
Which is not DMARD -
  1. ক
    Methotrexate
  2. খ
    Sulfasalazine
  3. গ
    Rifampicine
  4. ঘ
    Hydroxychloroquine
ব্যাখ্যা
Explanation :
The most common conventional DMARDs are methotrexate, sulfasalazine, hydroxychloroquine, and leflunomide. Azathioprine and other drugs are used much less frequently. 
২০.
Which is key determinant of antigen presentation to T-cell?
  1. ক
    ক) HLA complex
  2. খ
    খ) PTPN22
  3. গ
    গ) CTLA4
  4. ঘ
    ঘ) IL23R
ব্যাখ্যা
HLA complex is key determinant of antigen presentation to T-cell.
২১.
Radiographic hallmarks in RA excludes
  1. ক
    ক) Joint effusions
  2. খ
    খ) Juxta-articular osteopenia with erosions
  3. গ
    গ) Widening of the joint space
  4. ঘ
    ঘ) Loss of articular cartilage
ব্যাখ্যা

Radiographic hallmarks are
• Joint effusions
• Juxta-articular osteopenia with erosions
• Narrowing of the joint space
• Loss of articular cartilage

২২.
Which of the following is the hallmark of SLE?
  1. ক
    ক) Oral ulcer
  2. খ
    খ) Joint hypermobility
  3. গ
    গ) Skin rash
  4. ঘ
    ঘ) Production of autoantibodies
ব্যাখ্যা
Explanation: The hallmark of SLE is the production of autoantibodies Antibodies to double-stranded DNA and the so-called Smith (Sm) antigen are virtually diagnostic of SLE.
২৩.
Which antibody associated with SLE except -
  1. ক
    Anti Ds DNA
  2. খ
    ANA
  3. গ
    Anti Sm antibody
  4. ঘ
    ACPA
ব্যাখ্যা
Explanation -
Antibody raised in SLE :
ANA
Anti Ds DNA
Anti phospholipid antibody
Anti Sm antibody 

ACPA is anti citrullinated peptide antibodies raised in rheumatoid arthritis. 
২৪.
Which is not the symptoms of Rheumatic carditis -
  1. ক
    Dyspnea
  2. খ
    Chest pain
  3. গ
    Pulmonary oedema
  4. ঘ
    Swelling of the legs
ব্যাখ্যা
Explanation -
Symptoms of rheumatic carditis -
Dyspnoea 
Syncope
Chest pain,palpitation
Swelling of the legs.
২৫.
Seropositive arthritis -
  1. ক
    Septic arthritis
  2. খ
    Rheumatoid arthritis
  3. গ
    IBD associated arthopathy
  4. ঘ
    Gout
ব্যাখ্যা
Explanation :
Seropositive arthritis -
Rheumatoid arthritis 
Systemic lupus erythromatosus ( SLE) 
২৬.
Rheumatic heart disease most commonly affects
  1. ক
    ক) Mitral valve
  2. খ
    খ) Tricuspid valve
  3. গ
    গ) Aortic valve
  4. ঘ
    ঘ) Pulmonary valve
ব্যাখ্যা
• It most commonly affects the mitral valve and is responsible for 99% of acquired mitral stenosis
২৭.
‘Malar rash’ is a characteristic feature of which of the following?
  1. ক
    ক) SLE
  2. খ
    খ) RA
  3. গ
    গ) systemic sclerosis
  4. ঘ
    ঘ) Osteoarthritis
ব্যাখ্যা
Explanation: Malar rash of systemic lupus erythematosus, sparing the nasolabial folds. The rash is notably similar to rosacea
২৮.
Central tolerance of the immune system takes place in -
  1. ক
    ক) Bone marrow
  2. খ
    খ) Lymph nodes
  3. গ
    গ) Spleen
  4. ঘ
    ঘ) Tonsils
ব্যাখ্যা
Reference: Lange microbiology/14th/P-568
২৯.
DMRD in rheumatoid arthritis are -
  1. ক
    Infliximab
  2. খ
    Sulfasalazine
  3. গ
    Indomethacin
  4. ঘ
    Ketorolac
ব্যাখ্যা
Explanation :
DMRD used in rheumatoid arthritis -
Meyhotrexate
Sulfasalazine
Hydtoxychloroquine
Leflunomide