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Autoimmunity

মোট প্রশ্ন২৯এই পাতা২৯প্রতি পাতা১০০
ঘনত্ব
উত্তর
উত্তরিতবর্তমানপুনরায় দেখুনঅসম্পূর্ণ

Autoimmunity

PrepBank · পাতা / · ২৯ / ২৯

.
Campylobacter jejuni infection have been linked to
  1. ক) Gas gangrene
  2. খ) Myocarditis
  3. গ) GBS
  4. ঘ) Inflammatory bowel disease
সঠিক উত্তর:
গ) GBS
উত্তর
সঠিক উত্তর:
গ) GBS
ব্যাখ্যা
Explanation: Campylobacter species have been linked to GBS & post infectious reactive arthritis.
.
Which disease mostly affect sacroiliac joint -
  1. Psoriatic arthritis
  2. Rheumatoid arthritis
  3. SLE
  4. Ankylosing spondylitis
সঠিক উত্তর:
Ankylosing spondylitis
উত্তর
সঠিক উত্তর:
Ankylosing spondylitis
ব্যাখ্যা
Explanation :
Ankylosing spondylitis involve mostly sacroiliac joint and vertebra.
.
Psoriatic arthopathy -
  1. Asymmetrical inflammatory oligoarthritis
  2. Ankle joint involved
  3. CRP normal
  4. Skip lesion
সঠিক উত্তর:
Asymmetrical inflammatory oligoarthritis
উত্তর
সঠিক উত্তর:
Asymmetrical inflammatory oligoarthritis
ব্যাখ্যা
Explanation :
Psoriatic arthritis is a type of arthritis linked with psoriasis, a chronic skin and nail disease. Psoriasis causes red, scaly rashes and thick, pitted fingernails.
Mostly distal interphaleangeal joint involved
.
Not the feature of SLE -
  1. Discoid rash
  2. Tenosynuvitis
  3. Serositis
  4. Oral ulcer
সঠিক উত্তর:
Tenosynuvitis
উত্তর
সঠিক উত্তর:
Tenosynuvitis
.
ANA is 100% sensitive for which of the following disease?
  1. ক) Systemic sclerosis
  2. খ) Dermatomyositis
  3. গ) Rheumatoid arthritis
  4. ঘ) SLE
সঠিক উত্তর:
ঘ) SLE
উত্তর
সঠিক উত্তর:
ঘ) SLE
ব্যাখ্যা
Explanation: ANA is 100% sensitive for Systemic lupus erythematosus, Autoimmune hepatitis and Mixed connective tissue disease
.
Which is not the extrarticular features of rheuratoid arthritis -
  1. Fever
  2. Felty syndrome
  3. Episcleritis
  4. Urethritis
সঠিক উত্তর:
Urethritis
উত্তর
সঠিক উত্তর:
Urethritis
.
Which is not the extra articular feature of reactive arthritis -
  1. Circinate balanitis
  2. Ketatoderma blennorrhagica
  3. Buccal erosions
  4. Haematuria
সঠিক উত্তর:
Haematuria
উত্তর
সঠিক উত্তর:
Haematuria
ব্যাখ্যা
Explanation -
Extraarticular features of reactive arthritis -
Circinate balanitis
Keratoderma blennorrhagica
Nail dystrophy
Buccal erosions
.
Radiographic hallmarks in RA excludes
  1. ক) Joint effusions
  2. খ) Juxta-articular osteopenia with erosions
  3. গ) Widening of the joint space
  4. ঘ) Loss of articular cartilage
সঠিক উত্তর:
গ) Widening of the joint space
উত্তর
সঠিক উত্তর:
গ) Widening of the joint space
ব্যাখ্যা

Radiographic hallmarks are
 Joint effusions
 Juxta-articular osteopenia with erosions
 Narrowing of the joint space
 Loss of articular cartilage

.
Not true about JIA
  1. ক) Oligoarthritis is more common,
  2. খ) Large joints are affected more often than small joints,
  3. গ) Rheumatoid nodules and rheumatoid factor are usually present
  4. ঘ) Antinuclear antibody (ANA) seropositivity is common.
সঠিক উত্তর:
গ) Rheumatoid nodules and rheumatoid factor are usually present
উত্তর
সঠিক উত্তর:
গ) Rheumatoid nodules and rheumatoid factor are usually present
ব্যাখ্যা
• Oligoarthritis is more common,
• Systemic disease is more frequent,
• Large joints are affected more often than small joints,
• Rheumatoid nodules and rheumatoid factor are usually absent, and
• Antinuclear antibody (ANA) seropositivity is common.
১০.
Which immune cell is initiate autoimmune reaction in rheumatoid arthritis -
  1. NK cell
  2. CD4 + T lymphocyte
  3. CD8 + T lymphocyte
  4. Macrophage
সঠিক উত্তর:
CD4 + T lymphocyte
উত্তর
সঠিক উত্তর:
CD4 + T lymphocyte
ব্যাখ্যা
Explanation :
CD4 + T helper cells may initiate the autoimmune response in RA by reacting arthritogenic agent.
১১.
Criteria oaf arthritis in SLE excludes
  1. ক) Symmetrical
  2. খ) Mechanical
  3. গ) Principally affects small joint
  4. ঘ) Joints of hands & feet are involved
সঠিক উত্তর:
খ) Mechanical
উত্তর
সঠিক উত্তর:
খ) Mechanical
ব্যাখ্যা
• RA typically manifests as a symmetric arthritis principally affecting the small joints of the hand and feet.
১২.
Guillain Barre syndrome -
  1. Disease of CNS
  2. Related to desending paralysis
  3. 2/3rd cases recovered spontaneously
  4. Chronic inflammatory demyelinating polyneuropathy
সঠিক উত্তর:
2/3rd cases recovered spontaneously
উত্তর
সঠিক উত্তর:
2/3rd cases recovered spontaneously
ব্যাখ্যা
Explanation :
Guillain Barre syndrome ( Acute inflammatory demyelinating polyneuropathy) 
Causing ascending paralysis
Disease of perpheral nervous system.
১৩.
Coombs test is used for detecting -
  1. Haemolytic autoantibody
  2. Fetal aneuploidy
  3. Antigen detection
  4. Hepatitis B viral DNA
সঠিক উত্তর:
Haemolytic autoantibody
উত্তর
সঠিক উত্তর:
Haemolytic autoantibody
ব্যাখ্যা
Explanation :
Direct coombs test - Haemolytic autoantibody 
Indirect coombs test -
Rh antibody.
১৪.
Radiographic abnormalities of Rheumatoid arthritis is
  1. ক) Osteophytes
  2. খ) Joint space narrowing
  3. গ) Subchondral sclerosis
  4. ঘ) Joint deformity
সঠিক উত্তর:
খ) Joint space narrowing
উত্তর
সঠিক উত্তর:
খ) Joint space narrowing
ব্যাখ্যা

Radiographic abnormalities of Rheumatoid arthritis are:
 Periarticular osteoporosis
 Marginal joint erosions
 Joint subluxation
 Joint space narrowing

১৫.
Which is not seronegetive arthopathy -
  1. Psoriatic arthopathy
  2. Reactive arthritis
  3. Juvenile idiopathic arthritis
  4. Enteropathic arthritis
সঠিক উত্তর:
Juvenile idiopathic arthritis
উত্তর
সঠিক উত্তর:
Juvenile idiopathic arthritis
ব্যাখ্যা
Explanation :
Seronegetive arthritis -
Reactive arthritis
Psoriatic arthritis
Ankylosing spondylitis
Enteropathic arthritis
১৬.
Hallmark of SLE
  1. ক) Female predominant
  2. খ) Joint involvement
  3. গ) Skin rash
  4. ঘ) Production of autoantibodies
সঠিক উত্তর:
ঘ) Production of autoantibodies
উত্তর
সঠিক উত্তর:
ঘ) Production of autoantibodies
ব্যাখ্যা
The hallmark of SLE is the production of autoantibodies Antibodies to double-stranded DNA and the so-called Smith (Sm) antigen are virtually diagnostic of SLE.
১৭.
Which is not clinical triad of Grave's disease -
  1. Goiter
  2. Ophthalmoplagia
  3. Exophthalmos
  4. Pretibial myxoedema
সঠিক উত্তর:
Ophthalmoplagia
উত্তর
সঠিক উত্তর:
Ophthalmoplagia
ব্যাখ্যা
Explanation :
Clinical triad of Grave's disease :
Goiter
Exophthalmos
Pretibial myxoedema
১৮.
Rhematoid arthritis -
  1. Male : Female = 1:3
  2. No muscle wasting
  3. Age 2nd decade
  4. Thrombocytopenia present
সঠিক উত্তর:
Male : Female = 1:3
উত্তর
সঠিক উত্তর:
Male : Female = 1:3
ব্যাখ্যা
Explanation :
Rheumatoid arthritis :
Affect 3rd to 5th decade
Male : Female - 1:5
Anaemia present
Limitation of movement and muscle wasting
১৯.
Which is not DMARD -
  1. Methotrexate
  2. Sulfasalazine
  3. Rifampicine
  4. Hydroxychloroquine
সঠিক উত্তর:
Rifampicine
উত্তর
সঠিক উত্তর:
Rifampicine
ব্যাখ্যা
Explanation :
The most common conventional DMARDs are methotrexate, sulfasalazine, hydroxychloroquine, and leflunomide. Azathioprine and other drugs are used much less frequently. 
২০.
Which is key determinant of antigen presentation to T-cell?
  1. ক) HLA complex
  2. খ) PTPN22
  3. গ) CTLA4
  4. ঘ) IL23R
সঠিক উত্তর:
ক) HLA complex
উত্তর
সঠিক উত্তর:
ক) HLA complex
ব্যাখ্যা
HLA complex is key determinant of antigen presentation to T-cell.
২১.
Radiographic hallmarks in RA excludes
  1. ক) Joint effusions
  2. খ) Juxta-articular osteopenia with erosions
  3. গ) Widening of the joint space
  4. ঘ) Loss of articular cartilage
সঠিক উত্তর:
গ) Widening of the joint space
উত্তর
সঠিক উত্তর:
গ) Widening of the joint space
ব্যাখ্যা

Radiographic hallmarks are
• Joint effusions
• Juxta-articular osteopenia with erosions
• Narrowing of the joint space
• Loss of articular cartilage

২২.
Which of the following is the hallmark of SLE?
  1. ক) Oral ulcer
  2. খ) Joint hypermobility
  3. গ) Skin rash
  4. ঘ) Production of autoantibodies
সঠিক উত্তর:
ঘ) Production of autoantibodies
উত্তর
সঠিক উত্তর:
ঘ) Production of autoantibodies
ব্যাখ্যা
Explanation: The hallmark of SLE is the production of autoantibodies Antibodies to double-stranded DNA and the so-called Smith (Sm) antigen are virtually diagnostic of SLE.
২৩.
Which antibody associated with SLE except -
  1. Anti Ds DNA
  2. ANA
  3. Anti Sm antibody
  4. ACPA
সঠিক উত্তর:
ACPA
উত্তর
সঠিক উত্তর:
ACPA
ব্যাখ্যা
Explanation -
Antibody raised in SLE :
ANA
Anti Ds DNA
Anti phospholipid antibody
Anti Sm antibody 

ACPA is anti citrullinated peptide antibodies raised in rheumatoid arthritis. 
২৪.
Which is not the symptoms of Rheumatic carditis -
  1. Dyspnea
  2. Chest pain
  3. Pulmonary oedema
  4. Swelling of the legs
সঠিক উত্তর:
Pulmonary oedema
উত্তর
সঠিক উত্তর:
Pulmonary oedema
ব্যাখ্যা
Explanation -
Symptoms of rheumatic carditis -
Dyspnoea 
Syncope
Chest pain,palpitation
Swelling of the legs.
২৫.
Seropositive arthritis -
  1. Septic arthritis
  2. Rheumatoid arthritis
  3. IBD associated arthopathy
  4. Gout
সঠিক উত্তর:
Rheumatoid arthritis
উত্তর
সঠিক উত্তর:
Rheumatoid arthritis
ব্যাখ্যা
Explanation :
Seropositive arthritis -
Rheumatoid arthritis 
Systemic lupus erythromatosus ( SLE) 
২৬.
Rheumatic heart disease most commonly affects
  1. ক) Mitral valve
  2. খ) Tricuspid valve
  3. গ) Aortic valve
  4. ঘ) Pulmonary valve
সঠিক উত্তর:
ক) Mitral valve
উত্তর
সঠিক উত্তর:
ক) Mitral valve
ব্যাখ্যা
• It most commonly affects the mitral valve and is responsible for 99% of acquired mitral stenosis
২৭.
‘Malar rash’ is a characteristic feature of which of the following?
  1. ক) SLE
  2. খ) RA
  3. গ) systemic sclerosis
  4. ঘ) Osteoarthritis
সঠিক উত্তর:
ক) SLE
উত্তর
সঠিক উত্তর:
ক) SLE
ব্যাখ্যা
Explanation: Malar rash of systemic lupus erythematosus, sparing the nasolabial folds. The rash is notably similar to rosacea
২৮.
Central tolerance of the immune system takes place in -
  1. ক) Bone marrow
  2. খ) Lymph nodes
  3. গ) Spleen
  4. ঘ) Tonsils
সঠিক উত্তর:
ক) Bone marrow
উত্তর
সঠিক উত্তর:
ক) Bone marrow
ব্যাখ্যা
Reference: Lange microbiology/14th/P-568
২৯.
DMRD in rheumatoid arthritis are -
  1. Infliximab
  2. Sulfasalazine
  3. Indomethacin
  4. Ketorolac
সঠিক উত্তর:
Sulfasalazine
উত্তর
সঠিক উত্তর:
Sulfasalazine
ব্যাখ্যা
Explanation :
DMRD used in rheumatoid arthritis -
Meyhotrexate
Sulfasalazine
Hydtoxychloroquine
Leflunomide