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Necrosis

মোট প্রশ্ন১৫এই পাতা১৫প্রতি পাতা১০০
ঘনত্ব
উত্তর
উত্তরিতবর্তমানপুনরায় দেখুনঅসম্পূর্ণ

Necrosis

PrepBank · পাতা / · ১৫ / ১৫

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Type of necrosis in abscess-
  1. ক) Coagulative necrosis
  2. খ) Liquefactive necrosis
  3. গ) Caseous necrosis
  4. ঘ) Fat necrosis
সঠিক উত্তর:
খ) Liquefactive necrosis
উত্তর
সঠিক উত্তর:
খ) Liquefactive necrosis
ব্যাখ্যা
[Robbins 9th 43]
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Coagulative necrosis -
  1. Distinctive pattern of colliquitive necrosis
  2. Hypoxic death of solid tissues
  3. Basophila in cell
  4. Cell appears cheesy white appearance
সঠিক উত্তর:
Hypoxic death of solid tissues
উত্তর
সঠিক উত্তর:
Hypoxic death of solid tissues
ব্যাখ্যা
Explanation :
Coagulative necrosis is a form of necrosis in which the architecture of dead tissue is preserved for a span of at least some days .
The affected tissue has a firm texture. Presumably, the injury denatures not only structural proteins but also enzymes and so blocks the proteolysis of the dead cells; as a result, intensely eosinophilic cells with indistinct or reddish nuclei may persist for days or weeks.
Ultimately, the necrotic cells are broken down by the action of lysosomal enzymes derived from infiltrating leukocytes, which also remove the debris of the dead cells by phagocytosis. Ischemia caused by obstruction in a vessel may lead to coagulative necrosis of the supplied tissue in all organs except the brain (see next paragraph for explanation).
A localized area of coagulative necrosis is called an infarct.
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Enzymatic fat necrosis occurs in
  1. ক) Heart
  2. খ) Adrenal gland
  3. গ) Pancreas
  4. ঘ) Brain
সঠিক উত্তর:
গ) Pancreas
উত্তর
সঠিক উত্তর:
গ) Pancreas
ব্যাখ্যা
Enzymatic fat necrosis occurs in pancreas
.
Ischemic necrosis of brain indicates which type of necrosis?
  1. ক) Coagulative
  2. খ) Liquefactive
  3. গ) Caseous
  4. ঘ) Fibrinoid
সঠিক উত্তর:
খ) Liquefactive
উত্তর
সঠিক উত্তর:
খ) Liquefactive
ব্যাখ্যা

• Coagulative: ischemic necrosis of heart, kidney, liver, adrenal gland & other solid organs; gumma of tertiary syphilis
• Liquefactive: boil, abscess & ischemic necrosis of brain
• Caseous: Granuloma of TB
• Fat: Enzymatic-pancreas, Traumatic- breast
• Fibrinioid: in collagen disease

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Liquefactive necrosis is seen in -
  1. ক) Myocardial infarction
  2. খ) Abscess
  3. গ) Acute pancreatitis
  4. ঘ) Centre of granuloma
সঠিক উত্তর:
খ) Abscess
উত্তর
সঠিক উত্তর:
খ) Abscess
ব্যাখ্যা
Liquefactive necrosis is seen in abscess
.
Site of avuscular necrosis -
  1. Trochanter of femur
  2. Scaphoid bone
  3. Lateral meleolus
  4. Elbow joint
সঠিক উত্তর:
Scaphoid bone
উত্তর
সঠিক উত্তর:
Scaphoid bone
ব্যাখ্যা
Explanation :
Avuscular necrosis seen in :
Head of femur
Talas
Scaphoid
Radiation therapy
Sickle cell crisis
Trauma 
Tumor
.
Myocardial infraction is an example of -
  1. Coagulative necrosis
  2. Colliquitive necrosis
  3. Caseous necrosis
  4. Enzymatic fat necrosis
সঠিক উত্তর:
Coagulative necrosis
উত্তর
সঠিক উত্তর:
Coagulative necrosis
ব্যাখ্যা
Explanation :
Coagulative necrosis :
Occurs in solid organ except brain
Example - Infract of heart ( MI),Kidney,Spleen,Gumma of tertiary syphilis. 
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Feature of irreversible cell injury -
  1. Decreased Na pump
  2. Cellular swelling
  3. Intracellular activation of lysosomal enzymes
  4. Efflux of K+
সঠিক উত্তর:
Intracellular activation of lysosomal enzymes
উত্তর
সঠিক উত্তর:
Intracellular activation of lysosomal enzymes
ব্যাখ্যা
Explanation :
Features of irreversible cell injury -
Membrane injury
Intracellular release and activation of lysosomal enzyme 
Increase calcium influx
Decreased basophilia
Phagocytosis.
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Site of traumatic fat necrosis -
  1. Gut
  2. Breast
  3. Thyroid gland
  4. Liver
সঠিক উত্তর:
Breast
উত্তর
সঠিক উত্তর:
Breast
ব্যাখ্যা
Explanation :
Site of traumatic fat necrosis -
Mostly breast
Then- salivary gland 
Pancreas
Neonates after delivery. 
১০.
Not true about necrosis
  1. ক) Cellular swelling
  2. খ) Disrupted plasma membrane
  3. গ) Intact cellular content
  4. ঘ) Invariably pathological
সঠিক উত্তর:
গ) Intact cellular content
উত্তর
সঠিক উত্তর:
গ) Intact cellular content
১১.
Fibrinoid necrosis is seen in
  1. ক) SLE
  2. খ) Brain hypoxia
  3. গ) Tuberculosis
  4. ঘ) Boil
সঠিক উত্তর:
ক) SLE
উত্তর
সঠিক উত্তর:
ক) SLE
ব্যাখ্যা
Fibrinoid necrosis is seen in SLE
১২.
Necroptosis false statement -
  1. Is genetically programmed
  2. Is characterized by loss of ATP
  3. Is exclusively pathological
  4. Shows rupture of the cell membrane
সঠিক উত্তর:
Is exclusively pathological
উত্তর
সঠিক উত্তর:
Is exclusively pathological
ব্যাখ্যা
Explanation -
Necroptosis -is a hybrid that shares aspects of both necrosis and apoptosis. Morphologically, and to some extent biochemically, it resembles necrosis, as both are characterized by loss of ATP, swelling of the cell and organelles, generation of reactive oxygen species (ROS), release of lysosomal enzymes, and ultimately rupture of the plasma membrane.
Mechanistically, it is triggered by signal transduction pathways that culminate in cell death, a feature similar to apoptosis. Because of these overlapping features, necroptosis is sometimes called programmed necrosis to distinguish it from forms of necrosis driven passively by toxic or ischemic injury to the cell. 
Can occur both physiology and pathological condition.
১৩.
Which resembles necrosis morphologically & apoptosis mechanistically?
  1. ক) Pyroptosis
  2. খ) Necroptosis
  3. গ) Aponecrosis
  4. ঘ) Necropyroptosis
সঠিক উত্তর:
খ) Necroptosis
উত্তর
সঠিক উত্তর:
খ) Necroptosis
১৪.
Necroptosis occurs in-
  1. ক) Steatohepatitis
  2. খ) Acute pancreatitis
  3. গ) Reperfusion injury
  4. ঘ) All of above
সঠিক উত্তর:
ঘ) All of above
উত্তর
সঠিক উত্তর:
ঘ) All of above
ব্যাখ্যা
[Robbins 9th 59]
১৫.
Which of the following types of necrosis is most characteristic of abscess formation?
  1. ক) Coagulative
  2. খ) Enzymatic
  3. গ) Fibrinoid
  4. ঘ) Liquefactive
সঠিক উত্তর:
ঘ) Liquefactive
উত্তর
সঠিক উত্তর:
ঘ) Liquefactive
ব্যাখ্যা
Liquefactive necrosis occure in Pyogenic bacterial infection, brain hypoxia.