PrepBank · বিষয়ভিত্তিক প্রশ্ন
Pathology
Pathology
PrepBank · পাতা ৬ / ৭ · ৫০১–৬০০ / ৬৭০
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Inflammatory arthritis -
Morning stiffness - present
Joint pain - Worse after rest and improved after movement
Temperature - Raised
Joint effusion - Present
Joint crepitation - Absent
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Radiographic hallmarks are
• Joint effusions
• Juxta-articular osteopenia with erosions
• Narrowing of the joint space
• Loss of articular cartilage
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Sex cord tumor of ovary -
Leydig cell tumor
Sertoli cell tumor
Granulosa cell tumor
Thecoma
Fibroma
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Acute inflammatory oedema is due to -
Increased vascular permeability by endothelial cell contraction
Increased capillary hydrostatic pressure
Breakdown of large molecules of tissue proteins
Increased fluidity of the tissue ground substance.
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Signs of hyperthyroidism -
Exopthalmos
Lid retraction or lag
Tachycardia
Atrial fibrillation
Tremor
HTN
Goiter
Warm,moist skin
Muscle weakness
Pretibial myxoedema
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Unconjugated hyperbilirubinemia -
Haemolytic anaemia
Ineffective erythropoiesis
Reduced hepatic uptake
Breast milk jaundice
Physiologic jaundice
Gilbert syndrome
Conjugated hyperbilirubinemia -
Dublin johnson syndrome
Autoimmune cholangiopathies
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Major criteria of rheumatic fever :
Carditis
Polyarthritis( migratory)
Chorea
Erythema marginatum
Subcutaneous nodules
Minor criteria :
Fever
Arthalgia
Previous rheumatic fever
Raised ESR
Leucocytosis
First degree AV block
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Target organ damage by hypertension -
Blood vessels
Central nervous system
Retina
Heart
Kidneys
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Cells implicated tumor immunity -
Natural killer cell
Macrophage
Cytotoxic T cell
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Liver failure -
Hyperacute : <7 days
Acute : 8-28 days
Subacute : 29 days - 12 weeks.
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Major neurodegenerative disorder :
Alzheimer’s disese
Parkinson disese
Huntington disese
Spinocerebellar ataxia
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IDDM -
Age <40 years
Duration : Weeks
Body weight : Normal or low
Ketonuria, Hypoglycemia, complications : Present
Family history : Absent
Othet autoimmune disease : Present
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Urine R/M (Urine Routine & Microscopy) test involves gross, chemical, and microscopic evaluation of the urine sample.
Include physical appearence, urine protein, sugar, ketone body level,osmolarity,pH.
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Antibody raised in SLE :
ANA
Anti Ds DNA
Anti phospholipid antibody
Anti Sm antibody
ACPA is anti citrullinated peptide antibodies raised in rheumatoid arthritis.
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Benign childhood tumor -
Haemangioma
Lymphangioma
Benign fibrous tumor
Mature teratoma
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Cytokine of acute inflammation :
TNF, IL-1, IL-6, Chemokines
Cytokine of chronic inflammation :
IL-12, Gumma interferon, IL-17, All mediators of acute inflammation
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Complications of pneumonia-
Para- pneumonic effusion ( most common)
Empyema
Lung abscess
Lober collapse
Hepatitis,pericarditis
DVT
ARDS
Pneumothorax
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Symptoms of rheumatic carditis -
Dyspnoea
Syncope
Chest pain,palpitation
Swelling of the legs.
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Pathogenesis of osteoporosis -
Postmenopausal due to low peak bone mass
Genetic cause
Hypogonadism
Inflammatory bowel disease
Hyperparathyroidism
Cushing syndrome
Corticosteroid
GnRH agonist therapy
Alcohol excess
Heparin therapy
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AGN -
Age group : 6-12 years
Haematuria : Present
Hypertension : Present
Mild to moderate proteiniurea
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Transmission through Feco-oral route :
Hepatiris A & E
Polio
Rota
Coxsackie
Echo
Nowwalk virus
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• Metaplasia is a reversible change in which one differentiated cell type (epithelial or mesenchymal) is replaced by another cell type.
• Epithelial metaplasia is a double-edged sword
• It’s of 2 types. Epithelial & connective tissue metaplasia
• The most common epithelial metaplasia is columnar to squamous as occurs in the respiratory tract in response to chronic irritation.
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Seropositive arthritis -
Rheumatoid arthritis
Systemic lupus erythromatosus ( SLE)
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Decreased workload or disuse atrophy is seen in skeletal muscle in a patient with restricted to bed rest,or when immobilised in plaster cast.
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Causes of sudden cardiac death -
Heriditary or acquired abnormalities of the cardiac conduction system
Congenital coronary artery abnormalities
Mitral valve prolapse
Myocarditis or sarcoidosis
Dilated cardiomyopathy
Pulmonary hypertension
Myocardial hypertrophy
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Clinical features of cirthosis of liver -
Jaundice
Ascitis
Hepatomegaly
Spider nevi
Gynaecomastia
Loss of libido
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DNA -
a polymer composed of two polynucleotide chains that coil around each other to form a double helix.
The polymer carries genetic instructions for the development, functioning and growth.
Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a sugar called deoxyribose, and a phosphate group.
Purin base - Adenine and guanine
Pyrimidine base - Cytosine,Thymine,Uracil
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Cardinal signs of right heart failure -
Raised JVP
Ascities
Pitting oedema
Hepatomegaly
Cardinal signs of left heart failure :
Bilateral basal crepitation
Gallop rhythm
Pulsus alternans
Orthopnea
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Crepitation
Bronchial breath sound
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Crohns disease -
Bowel region : Ileum + colon
Distribution : Skip lesion
Stricture present
Transmural inflammation
Lymphoid reaction : Marked
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Disposable syringe is sterilized by -
Ethylene oxide
Ionizing radiation.
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Bilateral planter extension found in- structural lesions such as hemorrhage, brain and spinal cord tumors, and multiple sclerosis, and in abnormal metabolic states such as hypoglycemia, hypoxia, and anesthesia,infection - meningitis,encephalitis.
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A mnemonic to remember some of the cerebellar signs is DANISH.
Dysdiadokinesia / dysmetria.
Ataxia.
Nystagmus.
Intention tremor.
Speech - slurred or scanning.
Hypotonia.
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• Hypertrophy refers to an increase in the size of cells that result in an increase in the size of the affected organ.
• The hypertrophied organ has no new cells, just larger cells.
• The most common stimulus for hypertrophy of muscle is increased workload.
• Hypertrophy is the result of increased production of cellular proteins.
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IgM -
Immunoglobulin of primary immune response
Responsible for type II & Type III hypersensitivity
Acts a antigen receptor on B cell
Its a polymeric / pentameric form containing J chain
Highest molecular weight
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Causes of acute monoarthritis :
Septic arthritis
Gout
Pseudogout
Haemathroses
Trauma
Monoarticular presentation of polyarthritis
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In progressive phase of shock -
Persistent oxygen deficit leads to intracellular aerobic respiration is replaced by anaerobic glycolysis with excessive production of lactic acid. The resultant metabolic lactic acidosis lowers the tissue pH, which blunts the vasomotor response; arterioles dilate, and blood begins to pool in the microcirculation.
Peripheral pooling not only worsens the cardiac output but also puts endothelial cells at risk for the development of anoxic injury with subsequent DIC.
With widespread tissue hypoxia, vital organs are affected and begin to fail.
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Lower urinary tract symptoms :
Dysuria,Frequency, Urgency
Impaired urinary flow,Hesitency,Dribbling of urine,Incomplete emptying of bladder
Urinary retention
Incontinence