PrepBank · বিষয়ভিত্তিক প্রশ্ন
Physiology
Physiology
PrepBank · পাতা ৫ / ৯ · ৪০১–৫০০ / ৮৮৮
ব্যাখ্যা
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Cells contain a variety of organelles that perform specialized cell functions. The nucleus is an organelle that contains DNA and is the site of gene transcription. The endoplasmic reticulum and the Golgi apparatus are important in protein processing and the targeting of proteins to correct compartments within the cell. Lysosomes and peroxisomes are membranebound organelles that contribute to protein and lipid processing. Mitochondria are organelles that allow for oxidative phosphorylation in eukaryotic cells and also are important in specialized cellular signaling.
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Accessory digestive organs are those which help primary digestive organs in the process of digestion. Accessory digestive organs are:
• Teeth
• Tongue
• Salivary glands
• Exocrine part of pancreas
• Liver
• Gallbladder
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• Large & multipolar and Axons pass out in the anterior nerve roots as a-efferents
• Smaller nerve cells are multipolar and Axons pass out in anterior roots as y- efferents
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Explanation:
'P' wave may become tall peaked or broad and bifid (notched)
Tall, peaked: right atrial hypertrophy
Bifid broad: left atrial hypertrophy
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Explanation:
Manifestations of shock
• Decrease in cardiac output
• Low blood pressure
• Rapid thready pulse
• Pale and cold skin
• Increase in respiratory rate
• Restless or lethargy
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Urine volume can be as low as 0.5 L/day in a dehydrated person or as high as 20 L/day in a person who has been drinking tremendous amounts of water.
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Explanation:
At a normal heart rate the duration of systole and diastole are:
Atrial systole: 0.1 second
Atrial diastole: 0.7 second
Ventricular systole: 0.3 second
Ventricular diastole: 0.5 second
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Explanation:
Effect of exercise on cardiac output
Exercise increase cardiac output and it is proportionate exercise intensity. The responses to exercise are:
• Positive chronotropism (i.e. increase heart rate)
• Positive inotropism (i.e. increase myocardial contractility)
• Increase venous return and thus stroke volume
• Decrease in total peripheral resistance
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1. Factor ll(prothrombin)
2. Factor Vll
3. Factor IX
4. Factor X
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Messenger RNA , Ribosomal RNA, Transfer RNA
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Serum contains no fibrinogen
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The cell and the intracellular organelles are surrounded by semipermeable membranes. Biological membranes have a lipid bilayer core that is populated by structural and functional proteins. These proteins contribute greatly to the semipermeable properties of biological membrane.
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ABC of Biochemistry 6th - P:342
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The following are characteristics of fast fibers:
1. Fast fibers are large for great strength of contraction.
2. Fast fibers have an extensive sarcoplasmic reticulum for rapid release of calcium ions to initiate con- traction.
3. Large amounts of glycolytic enzymes are present in fast fibers for rapid release of energy by the glycolytic process.
4. Fast fibers have a less extensive blood supply than slow fibers because oxidative metabolism is of sec- ondary importance.
5. Fast fibers have fewer mitochondria than slow fibers, also because oxidative metabolism is secondary.
A deficit of red myoglobin in fast muscle gives it the name white muscle.
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During normal quiet respiration, only 3% to 5% of the total energy expended by the body is required for pulmonary ventilation. However, during heavy exercise, the amount of energy required can increase as much as 50-fold, especially if the person has any degree of increased airway resistance or decreased pulmo- nary compliance. Therefore, one of the major limitations on the intensity of exercise that can be performed is the person's ability to provide enough muscle energy for the respiratory process alone.
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The gene for the hormone has been cloned, and recombinant erythropoietin produced in animal cells is available for clinical use as epoetin alfa.
The recombinant erythropoietin is of value in the treatment of the anemia associated with kidney failure; 90% of the patients with end-stage renal disease who are undergoing dialysis are anemic as a result of erythropoietin deficiency. Erythropoietin is also used to stimulate red cell production in individuals who are banking a supply of their own blood in preparation for autologous transfusions during elective surgery (see Chapter 31).
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The cell and the intracellular organelles are surrounded by semipermeable membranes. Biological membranes have a lipid bilayer core that is populated by structural and functional proteins. These proteins contribute greatly to the semipermeable properties of biological membrane.
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· BEL ↓ (basophil, Eosinophil, Lymphocyte)
· PEN ↑ (Platelet, erythrocyte, neutrophil)
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★Bile salts are recirculated to the liver in the enterohepatic circulation via a Na+–bile acid cotransporter located in the ileum of the small intestine.
Reference-BRS physiology/6th/P-212/Fig-6.12
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Explanation:
Pathological causes of sinus bradycardia
• Hypothermia
• Hypothyroidism
• Myocardial infraction
• Raised intracranial pressure
• Cholestatic jaundice
• Drugs (beta-blockers, digoxin, antiarrhythmic drugs)
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Metabolic effects of prolonged vomiting are-
-Metabolic alkalosis
-Hypovolemia leading to lactic acidosis
-Hypokalemia
-Hypochloremia
-Paradoxical aciduria
-Compensatory hypoventilation
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Patients with liver disease secondary to d₁-antitrypsin deficiency usually present with dyspnoea (from emphysema), liver cirrhosis, cholestatic jaundice. Investigations include: serum a₁-antitrypsin levels, liver biopsy, genetic phenotyping and DNA analysis at prenatal diagnosis. Management involves quitting smoking, augmentation therapy with α₁-antitrypsin pooled from human plasma and liver transplantation is the treatment of choice in decompensated cirrhosis.
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Definition: It is an autoimmune disease in which circulating antibodies are formed against the TSH receptor and activates the thyroid gland hyperactive, resulting in development of goiter and hypersecretion of T3 & T4
More common in women
Clinical features:
1. Goiter with bruit
2. Exophthalmos-protrusion of the eye ball (it is the hallmark of Graves' disease)
3. Retraction of upper eye lid, lid lag
4. Corneal ulceration
5. Diplopia
6. Ophthalmoplegia
7. Papilledema
8. Loss of visual acuity
9. Vitiligo
10. Digital clubbing
11. Pretibial myxedema
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TCA cycle
Inhibition- ATP, NADH, Citratrate
Stimulation- ADP, NAD,Insulin
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Ø Increased serum total cholesterol and LDL-C
Ø Increased TAG (Triacyl glycerol)
Ø Hyponatremia (due to free water retention)
Ø Increased CPK (due to myopathy)
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Preparation before the test
· Unrestricted carbohydrate diet for 3 days
· Fasted overnight for at least 8 hrs
· Rest for 30 mins
· Remain seated for the duration of the test, with no smoking
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Metabolic effects of prolonged vomiting are-
-Metabolic alkalosis
-Hypovolemia leading to lactic acidosis
-Hypokalemia
-Hypochloremia
-Paradoxical aciduria
-Compensatory hypoventilation
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1. Convergence of the eyeballs due to contraction of the medial recti
2. Constriction of the pupil due to the contraction of constrictor pupillae of iris
3. Increase in the anterior curvature of the lens due to contraction of the ciliary muscle.
Ref : Sembulingam 6th edition (Page- 997)
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Ref : Sembulingam 6th edition (Page- 866)
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Explanations:
ESR>100 is regarded as sky rise. It occurs in
• Multiple myeloma
• Giant cell arteritis
• Severe infections
• Malignancy
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Androgens secreted by adrenal cortex:
Dehydroepiandrosterone
Androstenedione
Testosterone
Dehydroepiandrosterone is the most active adrenal androgen.
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Accessory digestive organs are those which help primary digestive organs in the process of digestion. Accessory digestive organs are:
• Teeth
• Tongue
• Salivary glands
• Exocrine part of pancreas
• Liver
• Gallbladder
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Ref : Sembulingam 6th edition (Table- 136.1)
Explanation : RMP of a nerve fibre is -70 mV, Firing level of a nerve fibre is -55 mv, End of depolarization of the nerve fibre is at +35 mV.
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1. Convergence of both eyeballs: It is necessary to bring the retinal images on to the corresponding points
2. Constriction of pupil: It is necessary to:
i. Increase the visual acuity by reducing lateral chromatic and spherical aberrations
ii. Reduce the quantity of light entering eye
iii. Increase the depth of focus through more central part of lens as its convexity is increased.
Ref : Sembulingam 6th edition (Page- 996)
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ABC of Biochemistry 6th - P:352
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Ref : Sembulingam 6th edition (Figure- 144.1)