১.
Example of type III hypersensitivity-
PrepBank · বিষয়ভিত্তিক প্রশ্ন
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
PrepBank · পাতা ১ / ১ · ১–১৫ / ১৫
২.
Highly specific for SLE
ব্যাখ্যা
Anti-dsDNA antibodies are highly specific (100%) for diagnosis of SLE. Its level correlates with lupus activity.
৩.
‘Malar rash’ is a Characteristic feature of-
ব্যাখ্যা
Explanation: Malar rash in SLE: Fixed erythema, flat or raised, sparing the nasolabial folds
৪.
Which antibody is useful in monitoring of SLE?
ব্যাখ্যা
Davidson Page 999
Anti-DNA antibodies bind to double-stranded DNA (dsDNA). They are useful in SLE monitoring as high titres are associated with more severe disease and an increase in antibody titre may precede relapse.
Anti-DNA antibodies bind to double-stranded DNA (dsDNA). They are useful in SLE monitoring as high titres are associated with more severe disease and an increase in antibody titre may precede relapse.
৫.
A 32-year-old woman presents with fever, arthralgia, and a malar rash across her face. Laboratory tests show positive antinuclear antibodies (ANA) and anti-dsDNA antibodies. What is the most likely diagnosis?
ব্যাখ্যা
Stem Breakdown:
Fever, arthritis, and a malar rash: These are classic symptoms of systemic lupus erythematosus (SLE), an autoimmune disease that can affect multiple organs.
Positive ANA and anti-dsDNA antibodies: These antibodies are highly specific for SLE, especially anti-dsDNA, which correlates with disease activity.
Option Analysis:
A) Rheumatoid arthritis: Rheumatoid arthritis primarily causes symmetric polyarthritis, particularly affecting the small joints of the hands and feet. It is not typically associated with a malar rash or positive anti-dsDNA antibodies.
B) Systemic lupus erythematosus (SLE): This is the correct diagnosis. Davidson and Harrison both emphasise that SLE is a systemic autoimmune disease characterised by a wide range of clinical features, including the malar (butterfly) rash, arthritis, renal involvement, and positive ANA and anti-dsDNA antibodies.
C) Dermatomyositis: Dermatomyositis is an inflammatory myopathy that causes muscle weakness and characteristic skin findings (e.g., heliotrope rash, Gottron’s papules), but it does not cause the malar rash or positive anti-dsDNA antibodies seen in SLE.
D) Sjögren’s syndrome: Sjögren’s syndrome is characterised by dry eyes and dry mouth due to autoimmune destruction of the salivary and lacrimal glands. It does not typically present with a malar rash or positive anti-dsDNA antibodies.
Fever, arthritis, and a malar rash: These are classic symptoms of systemic lupus erythematosus (SLE), an autoimmune disease that can affect multiple organs.
Positive ANA and anti-dsDNA antibodies: These antibodies are highly specific for SLE, especially anti-dsDNA, which correlates with disease activity.
Option Analysis:
A) Rheumatoid arthritis: Rheumatoid arthritis primarily causes symmetric polyarthritis, particularly affecting the small joints of the hands and feet. It is not typically associated with a malar rash or positive anti-dsDNA antibodies.
B) Systemic lupus erythematosus (SLE): This is the correct diagnosis. Davidson and Harrison both emphasise that SLE is a systemic autoimmune disease characterised by a wide range of clinical features, including the malar (butterfly) rash, arthritis, renal involvement, and positive ANA and anti-dsDNA antibodies.
C) Dermatomyositis: Dermatomyositis is an inflammatory myopathy that causes muscle weakness and characteristic skin findings (e.g., heliotrope rash, Gottron’s papules), but it does not cause the malar rash or positive anti-dsDNA antibodies seen in SLE.
D) Sjögren’s syndrome: Sjögren’s syndrome is characterised by dry eyes and dry mouth due to autoimmune destruction of the salivary and lacrimal glands. It does not typically present with a malar rash or positive anti-dsDNA antibodies.
৬.
Butterfly erythematous rash on cheeks can be found in-
ব্যাখ্যা
Ref: Macleod's Clinical Examination
৭.
Drug induced lupus is associated with following antibodies
ব্যাখ্যা
Ref: Davidson 23rd; P-992 , box : 24.10
৮.
Maternal antibody associated with neonatal lupus & congenital heart block
৯.
ANA is 100% sensitive for which disease?
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Davidson Page 998
১০.
Drug induced lupus is caused by-
১১.
Which is not Targets for antiphospholipid antibodies
ব্যাখ্যা
Targets for antiphospholipid antibodies
β2 -glycoprotein 1
Protein C Annexin V Prothrombin (may result in haemorrhagic presentation)
β2 -glycoprotein 1
Protein C Annexin V Prothrombin (may result in haemorrhagic presentation)
১২.
Which of the following skin condition is not seen in systemic lupus erythematosus?
১৩.
Which of the following is the most common cause of death in patients with systemic lupus erythematosus (SLE)?
ব্যাখ্যা
Infections are the leading cause of death in patients with systemic lupus erythematosus (SLE), as noted by Davidson. The immunosuppressive therapies used to control lupus, such as corticosteroids and cytotoxic drugs, increase the risk of severe infections. Harrison adds that while renal failure was once a leading cause of mortality in SLE, advances in treatment have improved long-term outcomes, with cardiovascular complications and infections now being more common causes of death.
১৪.
Which condition is associated with a "butterfly" facial rash?
ব্যাখ্যা
Answer: A
Explanation: The "butterfly" or malar rash is a hallmark feature of systemic lupus erythematosus (SLE), described in both Davidson and Harrison. This rash typically spares the nasolabial folds and is often triggered by sun exposure. SLE is a multisystem autoimmune disease, and skin manifestations like the malar rash are part of the diagnostic criteria.
Explanation: The "butterfly" or malar rash is a hallmark feature of systemic lupus erythematosus (SLE), described in both Davidson and Harrison. This rash typically spares the nasolabial folds and is often triggered by sun exposure. SLE is a multisystem autoimmune disease, and skin manifestations like the malar rash are part of the diagnostic criteria.
১৫.
Example of type III hypersensitivity-