Each kidney is approximately 10–13 cm in length in healthy adults;they are located retroperitoneally on either side of the aorta and inferior vena cava between the 12th thoracic and 3rd lumbar vertebrae (Fig. 18.1A). The right kidney is usually a few centimetres lower because the liver lies above it. Both kidneys rise and descend several centimetres with respiration.
৪.
Kidney produces following
ক
Erythropoietin
খ
Rennin
গ
D2
ঘ
Kinins
৫.
Macula densa is stimulated by
ক
Na
খ
K
গ
Mg
ঘ
Ca
৬.
Renal blood flow is ----- %of CO
ক
13
খ
15
গ
20
ঘ
25
৭.
Constriction of afferent arteriole causes no change in
ক
Filtration fraction
খ
RPF
গ
GFR
ঘ
Creatinine
৮.
Angiotension II does not work on
ক
Adrenal medulla
খ
Adrenal cortex
গ
Brain
ঘ
Vessel
৯.
Passive reabsorption in tubules occur for following
ক
Urea
খ
K
গ
Na
ঘ
Amino acid
১০.
Which is not true for sodium transport
ক
67% in PCT
খ
<1% in excretion
গ
10% in Thin descending limb
ঘ
25% in thick ascending limb
১১.
Medullary hyper osmolarity is maintained by
ক
active transport of ions
খ
passive diffusion of urea
গ
low medullary blood flow
ঘ
Diffusion of water
১২.
A 60 years old active smoker presented with disorientation. His Na level is 115 mmol/L. What is the cause?
ক
CCF
খ
NS
গ
SIADH
ঘ
Cushing syndrome
১৩.
Hyperkalemia is caused by
ক
Barter syndrome
খ
Liddle syndrome
গ
Gettleman syndrome
ঘ
congenital adrenal Hyperplasia
১৪.
Which of the following is not causing Hypokalaemia with hypertension
ক
Cushing's syndrome
খ
primary hyperaldosteronism
গ
Liddle's syndrome
ঘ
11-beta hydroxylase
১৫.
Acid base balance is maintained by -----no of equations
ক
1
খ
2
গ
3
ঘ
4
ব্যাখ্যা
2 equations 1.Hendersson Hasslebach equation 2.Anion Gap
১৬.
Metabolic acidosis is associated with all of the followings except:
ক
Methanol poisoning
খ
RTA
গ
Vomiting
ঘ
Lactic acidosis
১৭.
Which is not a cardinal feature of RTA type 1
ক
Normal anion gap metabolic acidosis
খ
Hyperkalemia
গ
Hypercalciuria and nephrocalcinosis
ঘ
Osteomalacia
ব্যাখ্যা
Type I RTA is characterized by:
•Impaired hydrogen ion secretion in Distal tubule •Hypokalemia •Hypocitraturia •Hypercalciuria •Nephrocalcinosis •Renal Stones
১৮.
Cause of Chloride responsive Metabolic alkalosis
ক
Conn’s syndrome
খ
Cushing’s syndrome
গ
Chronic hypokalemia
ঘ
Ingestion of Alkaline Drugs
ব্যাখ্যা
Saline/ Chloride responsive: Associated with hypovolemia and responds to N/S infusion
•Ingestion of Alkaline Drugs •GIT Cause •Diuretic administration
In adynamic bone disease following are increased except
ক
Ca
খ
PO4
গ
K
ঘ
PTH
২৪.
NS is associated with daily loss of------------protein
ক
2.5 gm
খ
3.5gm
গ
1.5gm
ঘ
4 gm
ব্যাখ্যা
1. Massive proteinuria, with the daily loss of 3.5 gm or more of protein (less in children) 2. Hypoalbuminemia, with plasma albumin levels less than 3 gm/dL 3. Generalized edema 4. Hyperlipidemia and lipiduria
২৫.
Proximal RTA is characterized by
ক
Failure to thrive
খ
Hyperphosphaturia
গ
Hypokalemia
ঘ
All
ব্যাখ্যা
Type II (proximal) RTA is characterized by •Hypokalemia •Hyperphosphaturia •Aminoaciduria •Glycosuria •Rickets and osteomalacia •Failure to thrive
২৬.
Type A lactic acidosis is caused by
ক
Cyanide
খ
Diabetes mellitus
গ
Severe sepsis
ঘ
Metformin
ব্যাখ্যা
Type B: Impaired Lactic acid metabolism •Severe sepsis •Hepatic & Renal failure •Drugs- Metformin, Ethanol •Diabetes mellitus Type A: Increased production, due to: Hypotension – Shock, Cardiac failure Tissue hypoxia: Mitochondrial dysfunction (CO, Cyanide) Severe anemia
২৭.
The minor unmeasured cations are
ক
gamma globulins
খ
magnesium
গ
Sodium
ঘ
calcium
ব্যাখ্যা
The major unmeasured cations are calcium, magnesium, gamma globulins.
২৮.
Renal Acid base balance is maintained by
ক
Reabsorption of filtered HCO3
খ
Secretion of H+
গ
Production of new HCO3
ঘ
All
২৯.
ECG changes in Hypokalemia
ক
Peaked T waves
খ
Prolonged QRS duration with bizarre QRS morphology
গ
Development of a sine wave appearance
ঘ
Apparent long QT interval
ব্যাখ্যা
ECG changes in Hypokalemia T wave flattening and inversion ·Prominent U wave ·Increased amplitude and width of the P wave ·Prolongation of the PR interval ·ST depression ·Apparent long QT interval (= long QU interval)
·Supraventricular tachyarrhythmias: AF, atrial flutter, atrial tachycardia ·life-threatening ventricular arrhythmias, e.g. VT, VF and Torsades de Pointes
৩০.
The earliest sign of hyperkalaemia is associated with