১.
Which of the following is not true about Chlorhexidine?
সঠিক উত্তর: ঘ
It is primarily fungicidal
উত্তর
সঠিক উত্তর: ঘ
It is primarily fungicidal
ব্যাখ্যা
Chlorhexidine – Summary Note
- Type: Cationic bisbiguanide antiseptic
- Formulations: Mouth rinse as CHX Gluconate (0.12%, 0.2%), gel, spray, chips
- Mechanism of Action:
- Disrupts bacterial cell membrane
- Causes leakage of cytoplasmic contents
- Bactericidal at high concentrations, bacteriostatic at low concentrations
- Spectrum:
- Broad-spectrum antimicrobial
- Effective against Gram-positive > Gram-negative bacteria
- Some antifungal & antiviral activity
- Substantivity:
- Binds to oral tissues and teeth
- Slow release maintains effect up to 12 hours
- Adverse Effects:
- Brown staining of teeth and tongue
- Altered taste sensation
- Mucosal irritation (rare)
- Increased calculus formation
- Contraindications:
- Known hypersensitivity to CHX
- Avoid immediate use after brushing (inactivated by anionic surfactants in toothpaste)
- Type: Cationic bisbiguanide antiseptic
- Formulations: Mouth rinse as CHX Gluconate (0.12%, 0.2%), gel, spray, chips
- Mechanism of Action:
- Disrupts bacterial cell membrane
- Causes leakage of cytoplasmic contents
- Bactericidal at high concentrations, bacteriostatic at low concentrations
- Spectrum:
- Broad-spectrum antimicrobial
- Effective against Gram-positive > Gram-negative bacteria
- Some antifungal & antiviral activity
- Substantivity:
- Binds to oral tissues and teeth
- Slow release maintains effect up to 12 hours
- Adverse Effects:
- Brown staining of teeth and tongue
- Altered taste sensation
- Mucosal irritation (rare)
- Increased calculus formation
- Contraindications:
- Known hypersensitivity to CHX
- Avoid immediate use after brushing (inactivated by anionic surfactants in toothpaste)